Influenza Vaccination Is Not Associated with a Reduction in the Risk of Recurrent Coronary Events

Acute respiratory infections, including influenza, have been suggested as possible precipitants of acute cardiac events. To evaluate whether influenza vaccination prevents recurrent coronary events, the authors conducted a population-based inception cohort study of 1,378 Group Health Cooperative enr...

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Bibliographic Details
Published in:American journal of epidemiology 2002-10, Vol.156 (7), p.634-640
Main Authors: Jackson, Lisa A., Yu, Onchee, Heckbert, Susan R., Psaty, Bruce M., Malais, Darren, Barlow, William E., Thompson, William W.
Format: Article
Language:English
Subjects:
Aged
Arteriosclerosis - epidemiology
Arteriosclerosis - prevention & control
Biological and medical sciences
Cardiology. Vascular system
confidence interval
Coronary heart disease
Female
hazard ratio
Heart
Humans
influenza
influenza vaccine
Influenza Vaccines
Influenza, Human - prevention & control
Male
Medical sciences
Middle Aged
myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - prevention & control
odds ratio
Proportional Hazards Models
Recurrence
Risk Factors
Washington - epidemiology
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Summary:Acute respiratory infections, including influenza, have been suggested as possible precipitants of acute cardiac events. To evaluate whether influenza vaccination prevents recurrent coronary events, the authors conducted a population-based inception cohort study of 1,378 Group Health Cooperative enrollees who survived a first myocardial infarction in 1992 through 1996. Recurrent coronary events, influenza vaccinations, and other covariates were identified by chart review and from administrative data systems. A Cox proportional hazards model was used to evaluate the association of receipt of each year’s influenza vaccine with subsequent risk of recurrent myocardial infarction and death from atherosclerotic cardiovascular disease. A total of 127 recurrent coronary events were identified during the median 2.3-year follow-up period. Influenza vaccination was not associated with risk of recurrent coronary events during the corresponding period of November through October (adjusted hazard ratio (HR) = 1.18, 95% confidence interval (CI): 0.79, 1.75) or during the corresponding periods of expected influenza activity (November through April) (HR = 1.06, 95% CI: 0.63, 1.78) or inactivity (May through October) (HR = 1.34, 95% CI: 0.76, 2.36). These results suggest that the benefit of influenza vaccine for older adults does not extend to protection against recurrent coronary events.
ISSN:0002-9262
1476-6256
0002-9262
DOI:10.1093/aje/kwf073