Activation energies and formation rate constants for organic arsenical-antidote adducts as determined by dynamic NMR spectroscopy

Phenyldichloroarsine reacts with 1,3-dimercapto-2-propanol and 1,2-dimercaptopropane to form 1:1 adducts in the form of a six-membered and five-membered heteroatom rings. Two geometric isomers for each compound are present in dynamic equilibrium. Rate constants and the activation barriers for the in...

Full description

Saved in:
Bibliographic Details
Published in:Chemical research in toxicology 1991-05, Vol.4 (3), p.295-299
Main Authors: Dill, Kilian, Huang, Lihua, Bearden, Daniel W, McGown, Evelyn L, O'Connor, Richard J
Format: Article
Language:English
Subjects:
Antidotes - chemistry
Arsenicals - chemistry
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Glycerol - analogs & derivatives
Glycerol - chemistry
Kinetics
Magnetic Resonance Spectroscopy - methods
Medical sciences
Metals and various inorganic compounds
Molecular Conformation
Propane - analogs & derivatives
Propane - chemistry
Spectrum Analysis - methods
Sulfhydryl Compounds - chemistry
Thermodynamics
Toxicology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phenyldichloroarsine reacts with 1,3-dimercapto-2-propanol and 1,2-dimercaptopropane to form 1:1 adducts in the form of a six-membered and five-membered heteroatom rings. Two geometric isomers for each compound are present in dynamic equilibrium. Rate constants and the activation barriers for the interconversion of the geometric isomers were determined by dynamic NMR spectroscopy. The activation barriers indicate that the five-membered heteroatom ring is more stable than the six-membered heteroatom ring.
ISSN:0893-228X
1520-5010
DOI:10.1021/tx00021a006