HER-2 in breast cancer—methods of detection, clinical significance and future prospects for treatment

The Human Epidermal Growth Factor (HER-2) oncogene encodes a transmembrane tyrosine kinase receptor with extensive homology to the Epidermal Growth Factor Receptor (EGFR) which is the prototypal member of this family of receptor tyrosine kinases. HER-2 gene amplification is found in 20–30% of breast...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2002-09, Vol.43 (3), p.231-244
Main Authors: Rampaul, R.S., Pinder, S.E., Gullick, W.J., Robertson, J.F.R., Ellis, I.O.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Breast Neoplasms - chemistry
Breast Neoplasms - diagnosis
Breast Neoplasms - therapy
Cancer Vaccines
Female
FISH
Gynecology. Andrology. Obstetrics
HER-2
Humans
Immunohistochemistry
Mammary gland diseases
Medical sciences
Molecular Diagnostic Techniques - methods
Molecular Diagnostic Techniques - trends
Prognosis
Receptor, ErbB-2 - analysis
Tumors
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Summary:The Human Epidermal Growth Factor (HER-2) oncogene encodes a transmembrane tyrosine kinase receptor with extensive homology to the Epidermal Growth Factor Receptor (EGFR) which is the prototypal member of this family of receptor tyrosine kinases. HER-2 gene amplification is found in 20–30% of breast cancers. Various methods such as immunohistochemistry, southern and slot blotting, enzyme immunoassays and fluorescence in situ hybridization have all been employed to evaluate HER-2 gene and protein abnormalities. Of these immunohistochemistry is the most frequently employed but there are valid indications for the other avaliable methods. However, it is prudent that whichever methods employed are standardized, especially those that possess may have a degree of subjectivity in their assesment.
ISSN:1040-8428
1879-0461
DOI:10.1016/S1040-8428(01)00207-4