HORMONAL MODULATION OF INTERLEUKIN-6, TUMOR NECROSIS FACTOR AND ASSOCIATED RECEPTOR SECRETION IN POSTMENOPAUSAL WOMEN

Hormone replacement therapy (HRT) reduces the risk for osteoporosis but transiently increases cardiovascular risk for some postmenopausal women. This study investigated the hypothesis that these risks are associated with HRT-induced changes in mononuclear cell secretion of interleukin-6 (IL-6), tumo...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2002-08, Vol.19 (4), p.193-200
Main Authors: Brooks-Asplund, Esther M., Tupper, Carrie E., Daun, Jane M., Kenney, W.Larry, Cannon, Joseph G.
Format: Article
Language:English
Subjects:
bone turnover/C-reactive protein/estrogen/FSH/progestin
C-Reactive Protein - metabolism
Cytokines - metabolism
Drug Combinations
Estrogens - pharmacology
Estrogens, Conjugated (USP) - pharmacology
Female
Follicle Stimulating Hormone - blood
Hormone Replacement Therapy
Humans
Interleukin-6 - metabolism
Leukocytes, Mononuclear - metabolism
Medroxyprogesterone Acetate - pharmacology
Osteocalcin - blood
Osteocalcin - metabolism
Postmenopause
Progestins - pharmacology
Receptors, Tumor Necrosis Factor - metabolism
Tumor Necrosis Factor-alpha - metabolism
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Summary:Hormone replacement therapy (HRT) reduces the risk for osteoporosis but transiently increases cardiovascular risk for some postmenopausal women. This study investigated the hypothesis that these risks are associated with HRT-induced changes in mononuclear cell secretion of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and associated soluble receptors. Compared to the untreated condition (n=8), estrogen therapy (n=7) and estrogen+progestin therapy (n=7) both caused 2-fold elevations in TNF-α secretion. IL-6 secretion was increased (48%, P=0.04) only by estrogen+progestin therapy. Although soluble receptor secretion was not different among groups, soluble TNF receptor type I and IL-6 receptor secretion were inversely related to plasma follicle stimulating hormone (P
ISSN:1043-4666
1096-0023
DOI:10.1006/cyto.2002.1963