The CD4-gp120 interaction and AIDS pathogenesis

Infection by the human immunodeficiency virus (HIV) leads to progressive destruction of the CD4+ subset of T lymphocytes, resulting in immunodeficiency and AIDS. The selectivity of CD4+ cell destruction is due to the specific binding of gp120, the external envelope glycoprotein of HIV, to CD4, initi...

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Bibliographic Details
Published in:Annual review of immunology 1991, Vol.9, p.649-678
Main Authors: Capon, D J, Ward, R H
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - etiology
Acquired Immunodeficiency Syndrome - therapy
AIDS/HIV
Amino Acid Sequence
Attachment Sites, Microbiological
Binding Sites
CD4 Antigens - metabolism
Cell Fusion
HIV Envelope Protein gp120 - chemistry
HIV Envelope Protein gp120 - metabolism
Humans
Molecular Sequence Data
Protein Binding
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Summary:Infection by the human immunodeficiency virus (HIV) leads to progressive destruction of the CD4+ subset of T lymphocytes, resulting in immunodeficiency and AIDS. The selectivity of CD4+ cell destruction is due to the specific binding of gp120, the external envelope glycoprotein of HIV, to CD4, initiating viral entry. Binding of gp120 to CD4 on the cell surface may also lead to CD4+ cell depletion by inappropriate immune targeting, and may interfere with CD4+ cell function and ontogeny by disrupting CD4-mediated cell signaling. The CD4-gp120 interaction is thus an obvious target for AIDS therapeutics.
ISSN:0732-0582