Metal versus plastic spacers: an in vitro and in vivo comparison

This study compared the metal Nebuchamber® with the polycarbonate Volumatic® spacer in vivo as well as in vitro. Seventeen asthmatic patients were evaluated in a crossover placebo-controlled double-blind study. Bronchodilation, heart rate and serum potassium levels were measured at baseline and 15 m...

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Bibliographic Details
Published in:International journal of pharmaceutics 2002-10, Vol.245 (1), p.93-98
Main Authors: Janssen, R, Weda, M, Ekkelenkamp, M.B, Lammers, J-W.J, Zanen, P
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
Albuterol - administration & dosage
Albuterol - therapeutic use
Asthma - drug therapy
Biological and medical sciences
Bronchodilation
Bronchodilator Agents - administration & dosage
Bronchodilator Agents - therapeutic use
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Female
General pharmacology
Humans
In vitro
Inhalation Spacers
Male
Medical sciences
Metals
Middle Aged
Nebuchamber
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Plastics
Respiratory system
Salbutamol
Volumatic
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Summary:This study compared the metal Nebuchamber® with the polycarbonate Volumatic® spacer in vivo as well as in vitro. Seventeen asthmatic patients were evaluated in a crossover placebo-controlled double-blind study. Bronchodilation, heart rate and serum potassium levels were measured at baseline and 15 min after administration of salbutamol. Cumulative dose-response curves (200, 400, 800 and 1600 μg) were constructed. The Andersen Cascade Impactor was used to compare the aerodynamic particle size distribution. The FEV 1 measurements showed highly significant differences between placebo and the two active preparations ( P0.05). In conclusion, there are no significant differences between the Volumatic® and Nebuchamber® either in vivo or in vitro.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(02)00330-7