Effect of Selective Cyclooxygenase‐2 Inhibition on the Development of Ligature‐Induced Periodontitis in Rats

Background: The purpose of this study was to evaluate the effect of a selective cyclooxygenase‐2 inhibitor on the progression of alveolar bone loss in an experimental periodontitis model in rats. Methods: One hundred eighty (180) Wistar rats were separated into 3 experimental groups. Cotton ligature...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2002-09, Vol.73 (9), p.1030-1036
Main Authors: Holzhausen, Marinella, Rossa, Carlos, Marcantonio, Elcio, Nassar, Patrícia O., Spolidório, Denise M.P., Spolidório, Luis C.
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - diagnostic imaging
Alveolar Bone Loss - prevention & control
Alveolar bone loss/prevention and control
Analysis of Variance
animal studies
Animals
Celecoxib
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
cyclooxygenase inhibitors
Cyclooxygenase Inhibitors - blood
Cyclooxygenase Inhibitors - therapeutic use
Dentistry
Disease Progression
Isoenzymes - antagonists & inhibitors
Leukocyte Count
Ligation
Male
Periodontitis - prevention & control
periodontitis/prevention and control
Prostaglandin-Endoperoxide Synthases
Pyrazoles
Radiography
Random Allocation
Rats
Rats, Wistar
Sulfonamides - blood
Sulfonamides - therapeutic use
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Summary:Background: The purpose of this study was to evaluate the effect of a selective cyclooxygenase‐2 inhibitor on the progression of alveolar bone loss in an experimental periodontitis model in rats. Methods: One hundred eighty (180) Wistar rats were separated into 3 experimental groups. Cotton ligatures were placed at the gingival margin level of lower right first molars. The rats were randomly assigned to one of the following groups that received: a daily oral dose of 10 mg/kg body weight of celecoxib (Cel); 20 mg/kg body weight of celecoxib (Ce2); or 10 ml/kg of saline solution (C). Serum levels of celecoxib and white blood cell count were determined. Standardized digital radiographs were taken after sacrifice at 3, 5, 10, 18, and 30 days to measure the amount of bone loss around the mesial root surface of the first molar tooth in each rat. Results: Two‐way analysis of variance (ANOVA) indicated that groups treated with celecoxib had significantly less bone loss compared to controls (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2002.73.9.1030