Fluorobalhimycin-A New Chapter in Glycopeptide Antibiotic Research

Mutasynthesis—a very potent tool? The two chlorine atoms attached to the aglycon of vancomycin‐type glycopeptide antibiotics (see structure) have considerable influence on the antibiotic activity of each compound. By combining molecular genetic methods and chemical synthesis these chlorine atoms can...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2002-09, Vol.41 (18), p.3383-3385
Main Authors: Weist, Stefan, Bister, Bojan, Puk, Oliver, Bischoff, Daniel, Pelzer, Stefan, Nicholson, Graeme J., Wohlleben, Wolfgang, Jung, Günther, Süssmuth, Roderich D.
Format: Article
Language:English
Subjects:
Actinomycetales - genetics
Actinomycetales - metabolism
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
antibiotics
balhimycin
Glycopeptides
mutasynthesis
Mutation
structure elucidation
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Summary:Mutasynthesis—a very potent tool? The two chlorine atoms attached to the aglycon of vancomycin‐type glycopeptide antibiotics (see structure) have considerable influence on the antibiotic activity of each compound. By combining molecular genetic methods and chemical synthesis these chlorine atoms can be replaced by fluorine atoms. The described approach may also be applicable to modifying other parts of the glycopeptide molecule.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020916)41:18<3383::AID-ANIE3383>3.0.CO;2-R