3',4'-trans-linked bicyclic nucleosides locked in S-type conformations

A novel class of 3',4'-trans-linked bicyclic nucleosides with locked S-type furanose conformations is introduced by synthesis of two model derivatives; one was obtained by cyclic ether formation and the other by ring-closing metathesis methodology.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2002-01 (17), p.1888-1889
Main Authors: Thomasen, Helena, Meldgaard, Michael, Freitag, Morten, Petersen, Michael, Wengel, Jesper, Nielsen, Poul
Format: Article
Language:English
Subjects:
Cyclization
Ethers, Cyclic - chemistry
Molecular Conformation
Nucleosides - chemistry
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Description
Summary:A novel class of 3',4'-trans-linked bicyclic nucleosides with locked S-type furanose conformations is introduced by synthesis of two model derivatives; one was obtained by cyclic ether formation and the other by ring-closing metathesis methodology.
ISSN:1359-7345
1364-548X
DOI:10.1039/b205031e