Spinal cord regeneration: intrinsic properties and emerging mechanisms

Injured spinal cord regenerates in adult fish and urodele amphibians, young tadpoles of anuran amphibians, lizard tails, embryonic birds and mammals, and in adults of at least some strains of mice. The extent of this regeneration is described with respect to axonal regrowth, neurogenesis, glial resp...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2002-10, Vol.13 (5), p.361-368
Main Authors: Chernoff, Ellen A.G, Sato, Kazuna, Corn, Angela, Karcavich, Rachel E
Format: Article
Language:English
Subjects:
amphibian regeneration
Animals
ependymal cell
Nerve Regeneration - physiology
neural stem cell
neurogenesis
Neurons - physiology
Spinal Cord - cytology
Spinal Cord - physiology
spinal cord regeneration
Stem Cells - physiology
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Summary:Injured spinal cord regenerates in adult fish and urodele amphibians, young tadpoles of anuran amphibians, lizard tails, embryonic birds and mammals, and in adults of at least some strains of mice. The extent of this regeneration is described with respect to axonal regrowth, neurogenesis, glial responses, and maintenance of an ‘embryonic’ environment. The regeneration process in amphibian spinal cord demonstrates that gap replacement and caudal regeneration share some properties with developing spinal cord. This review considers the extent to which intrinsically regenerating spinal cord demonstrates neural stem cell behavior and to what extent anterior–posterior and dorsal–ventral patterning might be involved.
ISSN:1084-9521
1096-3634
DOI:10.1016/S1084952102000927