"Spontaneous" FRA16B is a hot spot for sister chromatid exchanges

Six heterozygous carriers of a fragile site at 16q22 were available for the current study. We demonstrated that the observed fragile site was a "BrdUrd-sensitive" fra(16)(q22) or FRA16B, capable of spontaneous expression in some individuals (= "spontaneous" FRA16B). Significant d...

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Bibliographic Details
Published in:Human genetics 1991-09, Vol.87 (5), p.583-586
Main Authors: Lukusa, T, Meulepas, E, Fryns, J P, Van den Berghe, H, Cassiman, J J
Format: Article
Language:English
Subjects:
chromosome 16
Chromosome Banding
Chromosome Fragile Sites
Chromosome Fragility
Chromosomes, Human, Pair 16
Gene Frequency
Humans
Sister Chromatid Exchange
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Summary:Six heterozygous carriers of a fragile site at 16q22 were available for the current study. We demonstrated that the observed fragile site was a "BrdUrd-sensitive" fra(16)(q22) or FRA16B, capable of spontaneous expression in some individuals (= "spontaneous" FRA16B). Significant differences either in spontaneous or in ethylmethane sulfonate (EMS)-induced sister chromatid exchange (SCE) frequencies were found between the fragile 16q22 site, whether expressed or not, and its homologous normal site. These data complement our previous findings on FRAXA and provide additional arguments indicating that fragility and SCE are variable cytogenetic expressions of the same DNA structural alteration.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00209017