Klinefelter’s syndrome and precocious puberty: a harbinger for tumor

Boys with Klinefelter’s syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter’s syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed ty...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2002-09, Vol.60 (3), p.514-514
Main Authors: Kurzrock, Eric A, Tunuguntla, Hari Siva Gurunadha Rao, Busby, Joseph E, Gandour-Edwards, Regina, Goldman, Laurence A
Format: Article
Language:English
Subjects:
Child
Comorbidity
Diagnosis, Differential
Epidermal Cyst - diagnosis
Epidermal Cyst - epidemiology
Germinoma - diagnosis
Germinoma - epidemiology
Humans
Klinefelter Syndrome - diagnosis
Klinefelter Syndrome - epidemiology
Male
Mediastinal Neoplasms - diagnosis
Mediastinal Neoplasms - epidemiology
Puberty, Precocious - diagnosis
Puberty, Precocious - epidemiology
Testicular Neoplasms - diagnosis
Testicular Neoplasms - epidemiology
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Summary:Boys with Klinefelter’s syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter’s syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed type with seminomatous elements. The differential diagnosis of precocious puberty includes mediastinal tumors, especially in boys with Klinefelter’s syndrome.
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(02)01836-8