Investigation of an IL-2 polymorphism in patients with different levels of chronic periodontitis

Background: Interleukin‐2 (IL‐2) is a pro‐inflammatory cytokine derived from Th1 cells. This cytokine is involved in B‐cell activation and stimulates macrophages, natural killer cells, T‐cell proliferation and osteoclast activity. IL‐2 has been also implicated in the stimulation of osteoclast activi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical periodontology 2002-07, Vol.29 (7), p.587-591
Main Authors: Scarel-Caminaga, Raquel M., Trevilatto, Paula C., Souza, Ana P., Brito Jr, Rui B., Line, Sergio R. P.
Format: Article
Language:English
Subjects:
Adult
Alleles
Base Pairing - genetics
Chi-Square Distribution
Chronic Disease
chronic periodontitis
Confidence Intervals
Dentistry
DNA - genetics
Female
Gene Frequency - genetics
Genetic Markers - genetics
Genotype
Guanine
Heterozygote
Homozygote
Humans
interleukin-2
Interleukin-2 - genetics
Male
Odds Ratio
Periodontitis - genetics
Periodontitis - immunology
Phenotype
polymorphism
Polymorphism, Genetic - genetics
Promoter Regions, Genetic - genetics
risk factors
Thymine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Interleukin‐2 (IL‐2) is a pro‐inflammatory cytokine derived from Th1 cells. This cytokine is involved in B‐cell activation and stimulates macrophages, natural killer cells, T‐cell proliferation and osteoclast activity. IL‐2 has been also implicated in the stimulation of osteoclast activity in bone resorption. Objective: In this study the relationship between the polymorphism − 330 (T→G) in the IL‐2 gene and different levels of chronic periodontal disease was investigated. Material and Methods: DNA was extracted from buccal epithelial cells of 113 unrelated adult individuals acting as controls and with different levels of periodontitis. The PCR‐RFLP technique was used to investigate the polymorphism in the promoter of IL‐2 gene. Results: When comparing the data of three groups of patients (Control, Moderate and Severe) we did not find significant differences between the studied IL‐2 polymorphism and severity levels of PD. However, when the Control and Moderate phenotypes were grouped together and compared with genotypes TT vs. TG/GG, a significant difference was observed. Conclusion: We conclude that the − 330 (T→G) polymorphism in the IL‐2 gene is associated with the severity of periodontal disease. The results presented in this study suggest an active role of IL‐2 in the pathogenesis of periodontal disease.
ISSN:0303-6979
1600-051X
DOI:10.1034/j.1600-051X.2002.290701.x