Control of Growth and Differentiation of the Mammary Gland by Growth Factors

Mammary gland development is a complex process regulated by various steroid and polypeptide hormones. Although the systemic importance of hormones, such as estrogen, progesterone, prolactin, and growth hormone, in the growth of the mammary gland has been well documented, these hormones are virtually...

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Bibliographic Details
Published in:Journal of dairy science 1991-08, Vol.74 (8), p.2788-2800
Main Authors: Oka, Takami, Yoshimura, Masami, Lavandero, Sergio, Wada, Katsuya, Ohba, Yoshito
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Differentiation
epidermal growth factor
Epidermal Growth Factor - physiology
Female
Fibroblast Growth Factors - physiology
Fundamental and applied biological sciences. Psychology
growth factors
Growth Substances - physiology
histology
hormonal regulation
Insulin-Like Growth Factor I - physiology
mammary development
mammary glands
Mammary Glands, Animal - cytology
Mammary Glands, Animal - growth & development
mice
pregnancy
Pregnancy - physiology
receptors
Transforming Growth Factors - physiology
Vertebrates: reproduction
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Summary:Mammary gland development is a complex process regulated by various steroid and polypeptide hormones. Although the systemic importance of hormones, such as estrogen, progesterone, prolactin, and growth hormone, in the growth of the mammary gland has been well documented, these hormones are virtually incapable of stimulating mammary cell growth in vitro. Thus, the growth stimuli for mammary cells requires clarification. In recent years, a number of growth factors have been discovered; this has prompted interest in examining possible involvement of these biologically active agents in the process of mammary gland development. Results presented herein indicate that several growth factors including epidermal growth factor, transforming growth factor α and β, basic fibroblast growth factor, insulin-like growth factor-I, and mesenchyme-derived growth factor participate in the regulation of mammary cell growth and differentiation.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(91)78459-2