Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart

We describe the expression pattern of Sox8, Sox9 and Sox10 during the development of the chick embryo heart. These Sox genes constitute the group E of the large Sox family of transcription factors. We show that the expression of Sox8, Sox9 and Sox10 in the developing heart correlates with heart sept...

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Bibliographic Details
Published in:Mechanisms of development 2002-10, Vol.118 (1), p.199-202
Main Authors: Montero, J.A, Giron, B, Arrechedera, H, Cheng, Y.-C, Scotting, P, Chimal-Monroy, J, Garcia-Porrero, J.A, Hurle, J.M
Format: Article
Language:English
Subjects:
Aggrecan
Animals
Autonomic Nervous System - embryology
Chick Embryo
DNA-Binding Proteins - biosynthesis
Embryonic heart
Gene Expression
Heart - embryology
Heart Valves - embryology
High Mobility Group Proteins - biosynthesis
Sox10
Sox8
Sox9
SOX9 Transcription Factor
SOXE Transcription Factors
Time Factors
Tissue Distribution
Transcription Factors - biosynthesis
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Summary:We describe the expression pattern of Sox8, Sox9 and Sox10 during the development of the chick embryo heart. These Sox genes constitute the group E of the large Sox family of transcription factors. We show that the expression of Sox8, Sox9 and Sox10 in the developing heart correlates with heart septation and with the differentiation of the connective tissue of the valve leaflets. Sox10 appears also as a specific marker of developing heart nerves. These findings fit with the occurrence of morphological and functional anomalies of the heart reported in humans deficient for Sox9 and Sox10.
ISSN:0925-4773
1872-6356
DOI:10.1016/S0925-4773(02)00249-6