Nanocrystal Targeting in vivo

Inorganic nanostructures that interface with biological systems have recently attracted widespread interest in biology and medicine. Nanoparticles are thought to have potential as novel intravascular probes for both diagnostic (e.g., imaging) and therapeutic purposes (e.g., drug delivery). Critical...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-10, Vol.99 (20), p.12617-12621
Main Authors: Åkerman, Maria E., Warren C. W. Chan, Laakkonen, Pirjo, Bhatia, Sangeeta N., Ruoslahti, Erkki
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Biology
Blood vessels
Cardiovascular system
Coatings
Crystals
Drug Delivery Systems
Endothelial cells
Endothelium - cytology
Endothelium - metabolism
Homing
Humans
Lung - pathology
Lungs
Mice
Mice, Inbred BALB C
Mice, Nude
Microscopes
Microscopy, Fluorescence
Models, Biological
Mononuclear Phagocyte System - metabolism
Nanotechnology
Nanotechnology - methods
Neoplasm Transplantation
Neutrophils
Peptides - chemistry
Polyethylene Glycols - chemistry
Semiconductors
Surface-Active Agents - chemistry
Tumor Cells, Cultured
Tumors
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Summary:Inorganic nanostructures that interface with biological systems have recently attracted widespread interest in biology and medicine. Nanoparticles are thought to have potential as novel intravascular probes for both diagnostic (e.g., imaging) and therapeutic purposes (e.g., drug delivery). Critical issues for successful nanoparticle delivery include the ability to target specific tissues and cell types and escape from the biological particulate filter known as the reticuloendothelial system. We set out to explore the feasibility of in vivo targeting by using semiconductor quantum dots (qdots). Qdots are small (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.152463399