The Soma of RPeD1 Must Be Present for Long-Term Memory Formation of Associative Learning in Lymnaea

  1 Department of Physiology and Biophysics and   2 Department of Cell Biology and Anatomy, Faculty of Medicine, University of Calgary, Alberta T2N 4N1, Canada Scheibenstock, Andi, Darin Krygier, Zara Haque, Naweed Syed, and Ken Lukowiak. The Soma of RPeD1 Must Be Present for Long-Term Memory Format...

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Published in:Journal of neurophysiology 2002-10, Vol.88 (4), p.1584-1591
Main Authors: Scheibenstock, Andi, Krygier, Darin, Haque, Zara, Syed, Naweed, Lukowiak, Ken
Format: Article
Language:English
Subjects:
Animals
Association Learning - physiology
Conditioning, Operant - physiology
Denervation
Lymnaea
Lymnaea stagnalis
Memory - physiology
Neurites - physiology
Neurons - physiology
Neurons - ultrastructure
Respiration
Right Pedal Dorsal 1 neurons
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Summary:  1 Department of Physiology and Biophysics and   2 Department of Cell Biology and Anatomy, Faculty of Medicine, University of Calgary, Alberta T2N 4N1, Canada Scheibenstock, Andi, Darin Krygier, Zara Haque, Naweed Syed, and Ken Lukowiak. The Soma of RPeD1 Must Be Present for Long-Term Memory Formation of Associative Learning in Lymnaea . J. Neurophysiol. 88: 1584-1591, 2002. The cellular basis of long-term memory (LTM) storage is not completely known. We have developed a preparation where we are able to specify that a single identified neuron, Right Pedal Dorsal 1 (RPeD1), is a site of LTM formation of associative learning in the pond snail, Lymnaea stagnalis . We demonstrated this by ablating the soma of the neuron but leaving behind its functional primary neurite, as evidenced by electrophysiological and behavioral analyses. The soma-less RPeD1 neurite continues to be a necessary participant in the mediation of aerial respiratory behavior, associative learning, and intermediate-term memory (ITM); however, LTM cannot be formed. However, if RPeD1's soma is ablated after LTM consolidation has occurred, LTM can still be accessed. Thus the soma of RPeD1 is a site of LTM formation. * A. Scheibenstock, D. Krygier, and K. Lukowiak contributed equally to this work.
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.2002.88.4.1584