Genetic resistance to Salmonella typhimurium in two lines of chickens selected as resistant and sensitive on the basis of heterophil/lymphocyte ratio

1. A study was conducted to test for the validity of the heterophil/lymphocyte (H/L) ratio as a criterion for selection for resistance to Salmonella typhimurium in chickens. 2. An infective dose of S. typhimurium was given, directly in the crop, to two groups of chicken selected as Resistant (R) and...

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Bibliographic Details
Published in:British poultry science 2002-08, Vol.43 (4), p.501-507
Main Authors: Al-Murrani, W.K., Al-Rawi, I.K., Raof, N.M.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - biosynthesis
Body Weight
Breeding
Bursa of Fabricius - anatomy & histology
Chickens - genetics
Chickens - immunology
Female
Granulocytes - cytology
Hydrocortisone - blood
Immunity, Cellular
Immunity, Innate - genetics
Lymphocytes - cytology
Male
Organ Size
Phagocytosis
Poultry Diseases - genetics
Poultry Diseases - immunology
Poultry Diseases - mortality
Salmonella Infections, Animal - genetics
Salmonella Infections, Animal - immunology
Salmonella Infections, Animal - mortality
Salmonella typhimurium - immunology
Salmonella typhimurium - pathogenicity
Selection, Genetic
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Summary:1. A study was conducted to test for the validity of the heterophil/lymphocyte (H/L) ratio as a criterion for selection for resistance to Salmonella typhimurium in chickens. 2. An infective dose of S. typhimurium was given, directly in the crop, to two groups of chicken selected as Resistant (R) and Sensitive (S) on the bases of H/L ratio. The 99% lower confidence limit was used as a borderline; individuals below the limit were considered R and those above S. Many aspects of immune response were compared, namely: H/L ratio, antibody titre, cellular immunity, phagocytic activity, cortisol concentration, bursa and body weight. 3. The R group exceeded the S in all the studied variables of the immune response, indicating the possibility of using the H/L ratio and its confidence limit to select for general resistance. 4. Due to the within-strain variability in resistance, it seems that immunological and genetic studies should take into consideration separation of individuals into R and S before grouping. Failing to do so might lead to erroneous conclusions as a difference may simply be due to the different numbers of R and S included in each group.
ISSN:0007-1668
1466-1799
DOI:10.1080/0007166022000004408