Insulin-like growth factor-I and insulin as growth and differentiation factors in chicken embryogenesis

The avian embryo has been a useful model system for studies on the role of insulin and its close relative insulin-like growth factor-I (IGF-I) in development. The unfertilized chicken egg contains both peptides from maternal origin, and the embryo expresses insulin and IGF-I before the major organs...

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Bibliographic Details
Published in:Poultry science 1991-08, Vol.70 (8), p.1790-1796
Main Authors: De Pablo, F. (National Institutes of Health, Bethesda, MD), Robcis, H.L, Caldes, T, Alemany, J, Scavo, L, Serrano, J
Format: Article
Language:English
Subjects:
AGE
Animals
ARN MENSAJERO
ARN MESSAGER
Cell Differentiation
Chick Embryo - cytology
Chick Embryo - growth & development
DESARROLLO EMBRIONARIO
DEVELOPPEMENT EMBRYONNAIRE
DIFERENCIACION CELULAR
DIFFERENCIATION CELLULAIRE
EDAD
EMBRIONES ANIMALES
EMBRYON ANIMAL
EXPRESION GENICA
EXPRESSION DES GENES
FOIE
HIGADO
Insulin - physiology
Insulin-Like Growth Factor I - physiology
INSULINA
INSULINE
POLLITO
POUSSIN
RECEPTEUR D'HORMONE
Receptor, Insulin - analysis
RECEPTORES DE HORMONAS
Receptors, Cell Surface - analysis
Receptors, Somatomedin
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Summary:The avian embryo has been a useful model system for studies on the role of insulin and its close relative insulin-like growth factor-I (IGF-I) in development. The unfertilized chicken egg contains both peptides from maternal origin, and the embryo expresses insulin and IGF-I before the major organs are formed. lnsulin receptors and IGF-I receptors are found in the blastoderm and in all tissues examined during organogenesis. When exogenous insulin or IGF-I are added to the embryo, growth and differentiation events are stimulated. By contrast, insulin antibodies and insulin receptor antibodies retard embryo development. In embryos cultured ex ovo, in which growth is impaired, the levels of serum IGF-I are decreased
ISSN:0032-5791
1525-3171
DOI:10.3382/ps.0701790