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Characterization of a Neu/c-erbB-2 Protein-Specific Activating Factor

The neu oncogene encodes a tyrosine kinase with growth factor receptor-like properties. A neu protein-specific activating factor (NAF) was partially purified from medium conditioned by the transformed human T-cell line ATL-2. NAF was able to stimulate the tyrosine-specific kinase activity of the neu...

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Published in:	Proceedings of the National Academy of Sciences - PNAS 1991-10, Vol.88 (19), p.8582-8586
Main Authors:	Dobashi, Kunio, Davis, James G., Mikami, Yasunori, Freeman, Jonathan K., Hamuro, Junji, Greene, Mark I.
Format:	Article
Language:	English
Subjects:	Antibodies Biochemistry Biological and medical sciences Cell Division - drug effects Cell growth Cell Line Cell lines Cell physiology Dimerization Down-Regulation Enzyme Activation Fundamental and applied biological sciences. Psychology Humans Immunoprecipitation Internalization Ligands Macromolecular Substances Molecular and cellular biology Monoclonal antibodies Phosphotyrosine Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Receptor Aggregation Receptor, ErbB-2 Receptors Responses to growth factors, tumor promotors, other factors T-Lymphocytes - chemistry Tyrosine - analogs & derivatives Tyrosine - metabolism
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cited_by	cdi_FETCH-LOGICAL-c522t-808a1d5dbafa83f9cd47784a3de67075781088ebda5382136c473c5eb9e351263
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container_end_page	8586
container_issue	19
container_start_page	8582
container_title	Proceedings of the National Academy of Sciences - PNAS
container_volume	88
creator	Dobashi, Kunio Davis, James G. Mikami, Yasunori Freeman, Jonathan K. Hamuro, Junji Greene, Mark I.
description	The neu oncogene encodes a tyrosine kinase with growth factor receptor-like properties. A neu protein-specific activating factor (NAF) was partially purified from medium conditioned by the transformed human T-cell line ATL-2. NAF was able to stimulate the tyrosine-specific kinase activity of the neu protein (p185neu), induce dimerization and internalization, and increase the growth of cells bearing the neu protein. The effects of NAF were mediated by an interaction with the p185neuextracellular domain. NAF had no effect on the epidermal growth factor receptor kinase activity and no effect on cells that express that receptor. Further analysis of NAF and of other recently described neu protein-activating activities should help clarify the role of the neu protein in cell growth and transformation
doi_str_mv	10.1073/pnas.88.19.8582
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A neu protein-specific activating factor (NAF) was partially purified from medium conditioned by the transformed human T-cell line ATL-2. NAF was able to stimulate the tyrosine-specific kinase activity of the neu protein (p185neu), induce dimerization and internalization, and increase the growth of cells bearing the neu protein. The effects of NAF were mediated by an interaction with the p185neuextracellular domain. NAF had no effect on the epidermal growth factor receptor kinase activity and no effect on cells that express that receptor. 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Psychology ; Humans ; Immunoprecipitation ; Internalization ; Ligands ; Macromolecular Substances ; Molecular and cellular biology ; Monoclonal antibodies ; Phosphotyrosine ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins - metabolism ; Receptor Aggregation ; Receptor, ErbB-2 ; Receptors ; Responses to growth factors, tumor promotors, other factors ; T-Lymphocytes - chemistry ; Tyrosine - analogs & derivatives ; Tyrosine - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (19), p.8582-8586</ispartof><rights>Copyright 1991 The National Academy of Sciences of the United States of America</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-808a1d5dbafa83f9cd47784a3de67075781088ebda5382136c473c5eb9e351263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/88/19.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2357984$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2357984$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771,58216,58449</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5006201$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1717981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dobashi, Kunio</creatorcontrib><creatorcontrib>Davis, James G.</creatorcontrib><creatorcontrib>Mikami, Yasunori</creatorcontrib><creatorcontrib>Freeman, Jonathan K.</creatorcontrib><creatorcontrib>Hamuro, Junji</creatorcontrib><creatorcontrib>Greene, Mark I.</creatorcontrib><title>Characterization of a Neu/c-erbB-2 Protein-Specific Activating Factor</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The neu oncogene encodes a tyrosine kinase with growth factor receptor-like properties. A neu protein-specific activating factor (NAF) was partially purified from medium conditioned by the transformed human T-cell line ATL-2. NAF was able to stimulate the tyrosine-specific kinase activity of the neu protein (p185neu), induce dimerization and internalization, and increase the growth of cells bearing the neu protein. The effects of NAF were mediated by an interaction with the p185neuextracellular domain. NAF had no effect on the epidermal growth factor receptor kinase activity and no effect on cells that express that receptor. 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Psychology</subject><subject>Humans</subject><subject>Immunoprecipitation</subject><subject>Internalization</subject><subject>Ligands</subject><subject>Macromolecular Substances</subject><subject>Molecular and cellular biology</subject><subject>Monoclonal antibodies</subject><subject>Phosphotyrosine</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Receptor Aggregation</subject><subject>Receptor, ErbB-2</subject><subject>Receptors</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>T-Lymphocytes - chemistry</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNqFkUFv1DAQhS0EKkvhzAVQDqicsju249iRuJRVC0gVIAFna-I4ratsvNhOBfz6OuyyhQuc5vC-N_NGj5CnFJYUJF9tR4xLpZa0WSqh2D2yoNDQsq4auE8WAEyWqmLVQ_IoxmsAaISCI3JEJZWNogtytr7CgCbZ4H5icn4sfF9g8cFOK1Pa0L4pWfEp-GTdWH7eWuN6Z4pTk9xNpsfL4jx7fXhMHvQ4RPtkP4_J1_OzL-t35cXHt-_XpxelEYylUoFC2omuxR4V7xvTVVKqCnlnawlSSEVBKdt2KLhilNemktwI2zaWC8pqfkxe7_Zup3ZjO2PHFHDQ2-A2GH5oj07_rYzuSl_6Gy2YEDzbT_b24L9NNia9cdHYYcDR-ilqyajgsvo_SOs6J_sVaLUDTfAxBtsfslDQc0F6LkgrpWmj54Ky4_mfL9zxu0ay_nKvYzQ49AFH4-IBEwA1gxl7tcfm_b_Vuzu6n4Yh2e8pky_-SWbg2Q64jrnKA8G4yIEqfgtcdrol</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Dobashi, Kunio</creator><creator>Davis, James G.</creator><creator>Mikami, Yasunori</creator><creator>Freeman, Jonathan K.</creator><creator>Hamuro, Junji</creator><creator>Greene, Mark I.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19911001</creationdate><title>Characterization of a Neu/c-erbB-2 Protein-Specific Activating Factor</title><author>Dobashi, Kunio ; Davis, James G. ; Mikami, Yasunori ; Freeman, Jonathan K. ; Hamuro, Junji ; Greene, Mark I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-808a1d5dbafa83f9cd47784a3de67075781088ebda5382136c473c5eb9e351263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Antibodies</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Cell growth</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell physiology</topic><topic>Dimerization</topic><topic>Down-Regulation</topic><topic>Enzyme Activation</topic><topic>Fundamental and applied biological sciences. 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language	eng
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source	PubMed (Medline); JSTOR Archival Journals and Primary Sources Collection
subjects	Antibodies Biochemistry Biological and medical sciences Cell Division - drug effects Cell growth Cell Line Cell lines Cell physiology Dimerization Down-Regulation Enzyme Activation Fundamental and applied biological sciences. Psychology Humans Immunoprecipitation Internalization Ligands Macromolecular Substances Molecular and cellular biology Monoclonal antibodies Phosphotyrosine Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Receptor Aggregation Receptor, ErbB-2 Receptors Responses to growth factors, tumor promotors, other factors T-Lymphocytes - chemistry Tyrosine - analogs & derivatives Tyrosine - metabolism
title	Characterization of a Neu/c-erbB-2 Protein-Specific Activating Factor
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