Gastritis Induced by Helicobacter pylori in Gnotobiotic Piglets

Helicobacter pylori has recently been recognized as a gastric pathogen in humans. Experimental oral inoculation of gnotobiotic piglets with this organism results in gastritis that exhibits many features of the corresponding disease in humans. In piglets the organism is restricted to the gastric micr...

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Bibliographic Details
Published in:Reviews of infectious diseases 1991-07, Vol.13, p.S681-S685
Main Authors: Steven Krakowka, Eaton, Kathryn A., D. Michael Rings, Donna R. Morgan
Format: Article
Language:English
Subjects:
Animal models
Animals
Antibodies, Bacterial - biosynthesis
Bacterial colonization
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Disease Models, Animal
Gastritis
Gastritis - drug therapy
Gastritis - microbiology
Germ-Free Life
Gnotobiotics
Helicobacter Infections - drug therapy
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - immunology
Helicobacter pylori - pathogenicity
Human bacterial diseases
Humans
Infections
Infectious diseases
Inflammation
Medical sciences
Pathogenesis of Infection by Helicobacter pylori
Piglets
Stomach
Swine
Virulence
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Summary:Helicobacter pylori has recently been recognized as a gastric pathogen in humans. Experimental oral inoculation of gnotobiotic piglets with this organism results in gastritis that exhibits many features of the corresponding disease in humans. In piglets the organism is restricted to the gastric microenvironment and persists in that location despite prompt humoral and cellular responses to antigens of H. pylori. The gnotobiotic piglet model is useful for delineation of the role of suspected bacterial virulence factors (i.e., motility and urease production) in gastric colonization and for preclinical determination of the efficacy of various antimicrobial substances.
ISSN:0162-0886