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Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: The Cardiovascular Health Study

MRI-defined infarcts are common in the elderly. We sought to explore incidence, manifestations, and predictors of such infarcts. The Cardiovascular Health Study (CHS) is a population-based, longitudinal study of 5888 people aged > or =65 years. Participants have had extensive baseline and follow-...

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Bibliographic Details
Published in:Stroke (1970) 2002-10, Vol.33 (10), p.2376-2382
Main Authors: LONGSTRETH, W. T, DULBERG, Corinne, MANOLIO, Teri A, LEWIS, Michael R, BEAUCHAMP, Norman J, O'LEARY, Daniel, CARR, Jeff, FURBERG, Curt D
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Language:English
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Summary:MRI-defined infarcts are common in the elderly. We sought to explore incidence, manifestations, and predictors of such infarcts. The Cardiovascular Health Study (CHS) is a population-based, longitudinal study of 5888 people aged > or =65 years. Participants have had extensive baseline and follow-up evaluations; 1433 participants underwent 2 MRI scans separated by 5 years and had no infarcts on initial MRI. On follow-up MRI, 254 participants (17.7%) had 1 or more infarcts. Most were single (75.6%), subcortical (79.9%), and small (3 to 20 mm in 87.0%). Only 11.4% of those with infarcts experienced a documented transient ischemic attack or stroke between the scans. Although participants were similar at initial MRI, those with MRI-defined infarcts on follow-up experienced greater decline than those without infarcts on the Modified Mini-Mental State Examination and Digit-Symbol Substitution test (both P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000032241.58727.49