Determination of some histamine H1-receptor antagonists in dosage forms

Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2002-10, Vol.30 (3), p.859-867
Main Authors: GAZY, Azza A, MAHGOUB, Hoda, EL-YAZBI, F. A, EL-SAYED, M. A, RASHA, YOUSSEF, M
Format: Article
Language:English
Subjects:
Acetic Anhydrides - analysis
Analysis
Biological and medical sciences
Bromcresol Purple
Citric Acid - analysis
Dosage Forms
Eosine Yellowish-(YS)
General pharmacology
Histamine H1 Antagonists - administration & dosage
Histamine H1 Antagonists - analysis
Medical sciences
Pharmacology. Drug treatments
Spectrometry, Fluorescence - methods
Spectrophotometry - methods
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Summary:Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with chloroform and subsequently measured spectrophotometrically. Secondly, eosin gives with these drugs ion-pair complex, measurable directly without extraction both spectrophotometrically and spectrofluorimetrically. The last method involves the base-catalysed condensation of mixed anhydrides of organic acids (citric acid/acetic anhydride) where as the tertiary amino group in the above-cited drugs acts as the basic catalyst. The product of condensation is measured spectrophotometrically. All the reaction conditions for the proposed methods have been studied.
ISSN:0731-7085
1873-264X
DOI:10.1016/s0731-7085(02)00318-7