Effects of different us isolates of porcine reproductive and respiratory syndrome virus (PRRSV) on blood and bone marrow parameters of experimentally infected pigs

Seventy five-week-old, crossbred, caesarean-derived, colostrum-deprived pigs were randomly divided into five groups of 14 pigs and assigned one of five treatments: the intranasal inoculation of 105.7 TCID5O of one of four plaque-purified isolates of porcine reproductive and respiratory syndrome viru...

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Bibliographic Details
Published in:Veterinary record 2002-09, Vol.151 (12), p.344-348
Main Authors: Halbur, P.G., Evans, R., Hagemoser, W. A., Pallares, F. J., Rathje, J. A., Paul, P. S., Meng, X. J.
Format: Article
Language:English
Subjects:
Anemia - veterinary
Anemia - virology
Animals
Blood Cell Count - veterinary
Erythroid Precursor Cells - cytology
Erythroid Precursor Cells - virology
Hematocrit - veterinary
Hemoglobins - analysis
Myeloid Cells - cytology
Porcine Reproductive and Respiratory Syndrome - blood
Porcine Reproductive and Respiratory Syndrome - pathology
Porcine reproductive and respiratory syndrome virus
Porcine respiratory and reproductive syndrome virus - pathogenicity
Random Allocation
Swine
Swine Diseases - blood
Swine Diseases - virology
Virulence
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Summary:Seventy five-week-old, crossbred, caesarean-derived, colostrum-deprived pigs were randomly divided into five groups of 14 pigs and assigned one of five treatments: the intranasal inoculation of 105.7 TCID5O of one of four plaque-purified isolates of porcine reproductive and respiratory syndrome virus (PRRSV) (VR2385, VR2431, ISU-984 and ISU-22), or uninfected cell culture and media. Haematological variables were measured for 21 days and bone marrow was analysed when the pigs were killed three, seven, 10, 21 or 28 days after the inoculation. The PRRsv-infected pigs had non-regenerative anaemia and markedly increased myeloid:erythroid ratios from three to 21 days after inoculation. There was a significant (P
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.151.12.344