Dynamics of T Cells and TCR Excision Circles Differ After Treatment of Acute and Chronic HIV Infection

We quantified T cell proliferation and thymic function in primary HIV infection (PHI; n = 19) and chronic HIV infection (CHI; n = 14) by measuring Ki67 staining and TCR excision circle (TREC) number. After antiretroviral therapy of PHI there is a profound decrease in the number and percentage of Ki6...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2002-10, Vol.169 (8), p.4657-4666
Main Authors: Lewin, Sharon R, Ribeiro, Ruy M, Kaufmann, Gilbert R, Smith, Don, Zaunders, John, Law, Matthew, Solomon, Ajantha, Cameron, Paul U, Cooper, David, Perelson, Alan S
Format: Article
Language:English
Subjects:
Acute Disease
Antiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD4-Positive T-Lymphocytes - pathology
Cell Division - drug effects
Cell Division - immunology
Chronic Disease
Flow Cytometry
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - pathology
Humans
Immunophenotyping
Leukocyte Common Antigens - biosynthesis
Lymphocyte Count
Models, Immunological
Receptors, Antigen, T-Cell - blood
T-Lymphocyte Subsets - drug effects
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
T-Lymphocyte Subsets - pathology
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Summary:We quantified T cell proliferation and thymic function in primary HIV infection (PHI; n = 19) and chronic HIV infection (CHI; n = 14) by measuring Ki67 staining and TCR excision circle (TREC) number. After antiretroviral therapy of PHI there is a profound decrease in the number and percentage of Ki67(+) T cells (
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.169.8.4657