Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium

The expression of messenger RNA encoding neutral metalloproteinases and the tissue inhibitor of metalloproteinases (TIMP) in human arthritic synovium was evaluated in situ, using RNA probes. Interstitial collagenase and stromelysin were expressed by synovial lining cells in patients with active rheu...

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Bibliographic Details
Published in:Arthritis and rheumatism 1991-10, Vol.34 (9), p.1085-1093
Main Author: Spence Mccachren, S.
Format: Article
Language:English
Subjects:
Aged
Arthritis - metabolism
Arthritis - pathology
Arthritis - physiopathology
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - physiopathology
Biological and medical sciences
Diseases of the osteoarticular system
Gene Expression
Glycoproteins - genetics
Glycoproteins - metabolism
Humans
Immunohistochemistry
Inflammatory joint diseases
Medical sciences
Metalloendopeptidases - genetics
Metalloendopeptidases - metabolism
Microbial Collagenase - antagonists & inhibitors
Middle Aged
Osteoarthritis - metabolism
Osteoarthritis - pathology
Osteoarthritis - physiopathology
RNA, Messenger - genetics
RNA, Messenger - metabolism
Synovial Membrane - metabolism
Synovial Membrane - pathology
Synovial Membrane - physiopathology
Tissue Inhibitor of Metalloproteinases
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Summary:The expression of messenger RNA encoding neutral metalloproteinases and the tissue inhibitor of metalloproteinases (TIMP) in human arthritic synovium was evaluated in situ, using RNA probes. Interstitial collagenase and stromelysin were expressed by synovial lining cells in patients with active rheumatoid arthritis (RA). Proteinase messenger RNA was found both in cells expressing mononuclear phagocyte antigens and in cells that were negative for the antigens. TIMP was also expressed predominantly along the synovial lining layer. In highly inflammatory RA, TIMP expression appeared less intense than that of the proteases. In osteoarthritic synovium, TIMP was expressed at easily detectable levels, whereas the expression of collagenase and stromelysin was less prominent. The balance between expression of the metalloproteinases and of the metalloproteinase inhibitor in synovium appears to be altered during inflammation. These results are consistent with the notion that synovium plays different roles in the cartilage damage of RA and of osteoarthritis.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780340904