Inverse correlation of plasma leptin and soluble transferrin receptor levels in β-thalassemia patients

The aim of the study was to investigate the association of leptin with hematological parameters in beta-thalassemia patients in Greece. We measured plasma levels of soluble transferrin receptor (sTfR) and leptin by enzyme-linked immunosorbent assay (ELISA) in 40 beta-thalassemia patients (21 transfu...

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Bibliographic Details
Published in:Annals of hematology 2002-09, Vol.81 (9), p.543-547
Main Authors: DEDOUSSIS, G. V. Z, KYRTSONIS, M.-C, ANDRIKOPOULOS, N. E, VOSKARIDOU, E, LOUTRADIS, A
Format: Article
Language:English
Subjects:
Adult
Anemias. Hemoglobinopathies
beta-Thalassemia - blood
beta-Thalassemia - metabolism
Biological and medical sciences
Case-Control Studies
Diseases of red blood cells
Female
Greece - epidemiology
Hematologic and hematopoietic diseases
Heterozygote
Homozygote
Humans
Hypogonadism - blood
Hypogonadism - metabolism
Leptin - blood
Leptin - physiology
Male
Medical sciences
Middle Aged
Receptors, Leptin
Receptors, Transferrin - blood
Solubility
Statistics, Nonparametric
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Summary:The aim of the study was to investigate the association of leptin with hematological parameters in beta-thalassemia patients in Greece. We measured plasma levels of soluble transferrin receptor (sTfR) and leptin by enzyme-linked immunosorbent assay (ELISA) in 40 beta-thalassemia patients (21 transfusion dependent and 19 not transfused or sporadically transfused), in 20 beta-thalassemia carriers, and in 30 healthy individuals (HI). The percentage of reticulocytes (RET) was measured by the NE 9500 Sysmex automated method. Body mass index (BMI) was calculated by dividing body weight (kg) by square height (m). Endocrine measurements including sex hormones were also determined. sTfR concentrations were significantly higher in both transfusion-dependent (females 10.5+/-2.9, males 9.1+/-3.1) and non-transfusion-dependent patients (females 15.8+/-5.4, males 19.8+/-13.7) as compared to carriers (females 3.1+/-2.5, males 3.8+/-1.8) and to HI (females 1.5+/-1.2, males 2.5+/-2.1). Leptin levels were lower both in female and in male transfusion-dependent patients (0.5+/-0.3 and 1.2+/-1, respectively) and in non-transfused males (1.9+/-2) compared to carriers (females 7.9+/-2.7, males 13.1+/-9.1) and HI (females 14.6+/-6, males 7.5+/-3). There was a negative correlation between leptin and sTfR levels in transfused patients (R=-0.61, p
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-002-0499-7