Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoida...

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Bibliographic Details
Published in:Amino acids 2002-01, Vol.23 (1-3), p.213-216
Main Authors: Wieronska, J M, Szewczyk, B, Branski, P, Palucha, A, Pilc, A
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - metabolism
Antidepressive Agents - pharmacology
Antidepressive Agents, Tricyclic - metabolism
Antidepressive Agents, Tricyclic - pharmacology
Desipramine - metabolism
Desipramine - pharmacology
Excitatory Amino Acid Antagonists - metabolism
Excitatory Amino Acid Antagonists - pharmacology
Humans
Learning - drug effects
Learning - physiology
Male
Olfactory Bulb - surgery
Pyridines - metabolism
Pyridines - pharmacology
Rats
Rats, Wistar
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate - antagonists & inhibitors
Receptors, Metabotropic Glutamate - metabolism
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Summary:Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-001-0131-5