Novel nucleotide phosphonate analogues with potent antitumor activity

We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC 50 values in the μM range. The synthesis as well as structure–activity relationship are described. We have identified several nucleotide phosphonates demons...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2002-11, Vol.12 (21), p.3063-3066
Main Authors: Bubenik, Monica, Rej, Rabindra, Nguyen-Ba, Nghe, Attardo, Giorgio, Ouellet, France, Chan, Laval
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
Furans - chemical synthesis
Furans - pharmacology
General aspects
Humans
Medical sciences
Nucleotides - chemical synthesis
Nucleotides - pharmacology
Organophosphonates - chemical synthesis
Organophosphonates - pharmacology
Pharmacology. Drug treatments
Structure-Activity Relationship
Thymidine - metabolism
Tumor Cells, Cultured
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Summary:We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC 50 values in the μM range. The synthesis as well as structure–activity relationship are described. We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC 50 values in the μM range. The synthesis as well as structure–activity relationship are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)00679-0