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Numerical chromosomal abnormality in gastric MALT lymphoma and diffuse large B-cell lymphoma
We investigated numerical chromosomal abnormalities, using the fluorescence in situ hybridization (FISH) method, in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBL). We also compared the histopathological findings, including the presence or absence o...
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| Published in: | Journal of gastroenterology 2002-09, Vol.37 (9), p.691-696 |
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| container_issue | 9 |
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| container_title | Journal of gastroenterology |
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| creator | Watanobe, Ikuo Takamori, Shigeru Kojima, Kuniaki Fukasawa, Masaki Beppu, Tomoe Futagawa, Shunji Hirai, Shu |
| description | We investigated numerical chromosomal abnormalities, using the fluorescence in situ hybridization (FISH) method, in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBL). We also compared the histopathological findings, including the presence or absence of Helicobacter pylori infection, with the analytical results.
Sixteen patients who underwent operation for malignant gastric lymphoma in our department were divided into three groups: patients with low-grade gastric MALT lymphoma (l-MALT; n = 5), those with high-grade gastric MALT lymphoma (h-MALT; n = 8), and those with DLBL (n = 3). Numerical abnormalities of chromosomes 8, 9, 12, and 17 were investigated by the FISH method, and the presence or absence of H. pylori infection was microscopically examined.
Numerical abnormality was observed in chromosome 12 in 11 patients (68.8%), in chromosome 8 in 10 (62.5%), and in chromosome 17 in 5 (31.3%), showing a high frequency. H. pylori infection was detected in 80% and 50% of patients with l-MALT and h-MALT, respectively, but no H. pylori infection was observed in patients with DLBL.
A new biological characteristic of gastric MALT lymphoma was obtained, i.e., a high frequency of numerical abnormalities of chromosomes 12, 8, and 17. There was no correlation between the numerical chromosomal abnormalities and the clinicopathological findings. |
| doi_str_mv | 10.1007/s005350200113 |
| format | article |
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Sixteen patients who underwent operation for malignant gastric lymphoma in our department were divided into three groups: patients with low-grade gastric MALT lymphoma (l-MALT; n = 5), those with high-grade gastric MALT lymphoma (h-MALT; n = 8), and those with DLBL (n = 3). Numerical abnormalities of chromosomes 8, 9, 12, and 17 were investigated by the FISH method, and the presence or absence of H. pylori infection was microscopically examined.
Numerical abnormality was observed in chromosome 12 in 11 patients (68.8%), in chromosome 8 in 10 (62.5%), and in chromosome 17 in 5 (31.3%), showing a high frequency. H. pylori infection was detected in 80% and 50% of patients with l-MALT and h-MALT, respectively, but no H. pylori infection was observed in patients with DLBL.
A new biological characteristic of gastric MALT lymphoma was obtained, i.e., a high frequency of numerical abnormalities of chromosomes 12, 8, and 17. There was no correlation between the numerical chromosomal abnormalities and the clinicopathological findings.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s005350200113</identifier><identifier>PMID: 12375141</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Chromosome Aberrations ; Chromosomes, Human, Pair 12 - genetics ; Chromosomes, Human, Pair 17 - genetics ; Chromosomes, Human, Pair 8 - genetics ; Chromosomes, Human, Pair 9 - genetics ; Female ; Helicobacter Infections - genetics ; Helicobacter Infections - microbiology ; Helicobacter Infections - pathology ; Helicobacter pylori - isolation & purification ; Humans ; In Situ Hybridization, Fluorescence ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - microbiology ; Lymphoma, B-Cell - pathology ; Lymphoma, B-Cell, Marginal Zone - genetics ; Lymphoma, B-Cell, Marginal Zone - microbiology ; Lymphoma, B-Cell, Marginal Zone - pathology ; Lymphoma, Large B-Cell, Diffuse - genetics ; Lymphoma, Large B-Cell, Diffuse - microbiology ; Lymphoma, Large B-Cell, Diffuse - pathology ; Male ; Middle Aged ; Retrospective Studies ; Stomach Neoplasms - genetics ; Stomach Neoplasms - microbiology ; Stomach Neoplasms - pathology</subject><ispartof>Journal of gastroenterology, 2002-09, Vol.37 (9), p.691-696</ispartof><rights>Springer-Verlag Tokyo 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-e0be3656e0b23550f5e33042240721f028a77ab577f5937ce86b17bb47d0a0c13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12375141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanobe, Ikuo</creatorcontrib><creatorcontrib>Takamori, Shigeru</creatorcontrib><creatorcontrib>Kojima, Kuniaki</creatorcontrib><creatorcontrib>Fukasawa, Masaki</creatorcontrib><creatorcontrib>Beppu, Tomoe</creatorcontrib><creatorcontrib>Futagawa, Shunji</creatorcontrib><creatorcontrib>Hirai, Shu</creatorcontrib><title>Numerical chromosomal abnormality in gastric MALT lymphoma and diffuse large B-cell lymphoma</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><description>We investigated numerical chromosomal abnormalities, using the fluorescence in situ hybridization (FISH) method, in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBL). We also compared the histopathological findings, including the presence or absence of Helicobacter pylori infection, with the analytical results.
Sixteen patients who underwent operation for malignant gastric lymphoma in our department were divided into three groups: patients with low-grade gastric MALT lymphoma (l-MALT; n = 5), those with high-grade gastric MALT lymphoma (h-MALT; n = 8), and those with DLBL (n = 3). Numerical abnormalities of chromosomes 8, 9, 12, and 17 were investigated by the FISH method, and the presence or absence of H. pylori infection was microscopically examined.
Numerical abnormality was observed in chromosome 12 in 11 patients (68.8%), in chromosome 8 in 10 (62.5%), and in chromosome 17 in 5 (31.3%), showing a high frequency. H. pylori infection was detected in 80% and 50% of patients with l-MALT and h-MALT, respectively, but no H. pylori infection was observed in patients with DLBL.
A new biological characteristic of gastric MALT lymphoma was obtained, i.e., a high frequency of numerical abnormalities of chromosomes 12, 8, and 17. There was no correlation between the numerical chromosomal abnormalities and the clinicopathological findings.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 12 - genetics</subject><subject>Chromosomes, Human, Pair 17 - genetics</subject><subject>Chromosomes, Human, Pair 8 - genetics</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Female</subject><subject>Helicobacter Infections - genetics</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, B-Cell - microbiology</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, B-Cell, Marginal Zone - genetics</subject><subject>Lymphoma, B-Cell, Marginal Zone - microbiology</subject><subject>Lymphoma, B-Cell, Marginal Zone - pathology</subject><subject>Lymphoma, Large B-Cell, Diffuse - genetics</subject><subject>Lymphoma, Large B-Cell, Diffuse - microbiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - pathology</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpd0DtPwzAUBWALgWgpjKzILGyBe_2Ik7FUvKQCS9mQIidx2lRJXOxk6L_HVSsQTPcOn46ODiGXCLcIoO48gOQSGAAiPyJjFFxGMmXsmIwhFSJCVGJEzrxfB8JBJqdkhIwriQLH5PNtaI2rC93QYuVsa71tw6_zzrrw1P2W1h1dat8HRF-n8wVttu1mFRTVXUnLuqoGb2ij3dLQ-6gwTfMjzslJpRtvLg53Qj4eHxaz52j-_vQym86jgsdJHxnIDY9lHC7jUkIlDecgGBOgGFbAEq2UzqVSlUy5KkwS56jyXKgSNBTIJ-Rmn7tx9mswvs_a2u-a6M7YwWchJVYylQFe_4NrO7gudMuSFCFN-S4s2pvCWe-dqbKNq1vtthlCtps8-zN58FeHzCFvTfmrDxvzb3gzekE</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Watanobe, Ikuo</creator><creator>Takamori, Shigeru</creator><creator>Kojima, Kuniaki</creator><creator>Fukasawa, Masaki</creator><creator>Beppu, Tomoe</creator><creator>Futagawa, Shunji</creator><creator>Hirai, Shu</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20020901</creationdate><title>Numerical chromosomal abnormality in gastric MALT lymphoma and diffuse large B-cell lymphoma</title><author>Watanobe, Ikuo ; Takamori, Shigeru ; Kojima, Kuniaki ; Fukasawa, Masaki ; Beppu, Tomoe ; Futagawa, Shunji ; Hirai, Shu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-e0be3656e0b23550f5e33042240721f028a77ab577f5937ce86b17bb47d0a0c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 12 - 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Academic</collection><collection>ComDisDome</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanobe, Ikuo</au><au>Takamori, Shigeru</au><au>Kojima, Kuniaki</au><au>Fukasawa, Masaki</au><au>Beppu, Tomoe</au><au>Futagawa, Shunji</au><au>Hirai, Shu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Numerical chromosomal abnormality in gastric MALT lymphoma and diffuse large B-cell lymphoma</atitle><jtitle>Journal of gastroenterology</jtitle><addtitle>J Gastroenterol</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>37</volume><issue>9</issue><spage>691</spage><epage>696</epage><pages>691-696</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>We investigated numerical chromosomal abnormalities, using the fluorescence in situ hybridization (FISH) method, in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBL). We also compared the histopathological findings, including the presence or absence of Helicobacter pylori infection, with the analytical results.
Sixteen patients who underwent operation for malignant gastric lymphoma in our department were divided into three groups: patients with low-grade gastric MALT lymphoma (l-MALT; n = 5), those with high-grade gastric MALT lymphoma (h-MALT; n = 8), and those with DLBL (n = 3). Numerical abnormalities of chromosomes 8, 9, 12, and 17 were investigated by the FISH method, and the presence or absence of H. pylori infection was microscopically examined.
Numerical abnormality was observed in chromosome 12 in 11 patients (68.8%), in chromosome 8 in 10 (62.5%), and in chromosome 17 in 5 (31.3%), showing a high frequency. H. pylori infection was detected in 80% and 50% of patients with l-MALT and h-MALT, respectively, but no H. pylori infection was observed in patients with DLBL.
A new biological characteristic of gastric MALT lymphoma was obtained, i.e., a high frequency of numerical abnormalities of chromosomes 12, 8, and 17. There was no correlation between the numerical chromosomal abnormalities and the clinicopathological findings.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>12375141</pmid><doi>10.1007/s005350200113</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Chromosome Aberrations Chromosomes, Human, Pair 12 - genetics Chromosomes, Human, Pair 17 - genetics Chromosomes, Human, Pair 8 - genetics Chromosomes, Human, Pair 9 - genetics Female Helicobacter Infections - genetics Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori - isolation & purification Humans In Situ Hybridization, Fluorescence Lymphoma, B-Cell - genetics Lymphoma, B-Cell - microbiology Lymphoma, B-Cell - pathology Lymphoma, B-Cell, Marginal Zone - genetics Lymphoma, B-Cell, Marginal Zone - microbiology Lymphoma, B-Cell, Marginal Zone - pathology Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - microbiology Lymphoma, Large B-Cell, Diffuse - pathology Male Middle Aged Retrospective Studies Stomach Neoplasms - genetics Stomach Neoplasms - microbiology Stomach Neoplasms - pathology |
| title | Numerical chromosomal abnormality in gastric MALT lymphoma and diffuse large B-cell lymphoma |
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