The hypercycle. Coupling of RNA and protein biosynthesis in the infection cycle of an RNA bacteriophage

It is necessary not only to describe hypercycles in vivo but also to reduce the chemical steps involved to an in vitro level where the tools of biochemistry, and in particular biochemical kinetics, can be applied for analysis. We were able to do this for a particular example, the infection cycle of...

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Bibliographic Details
Published in:Biochemistry (Easton) 1991-11, Vol.30 (46), p.11005-11018
Main Authors: Eigen, Manfred, Biebricher, Christof K, Gebinoga, Michael, Gardiner, William C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Microbiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
RNA Phages - growth & development
RNA Phages - metabolism
RNA, Viral - biosynthesis
Viral Proteins - biosynthesis
Virology
Virus Replication
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Summary:It is necessary not only to describe hypercycles in vivo but also to reduce the chemical steps involved to an in vitro level where the tools of biochemistry, and in particular biochemical kinetics, can be applied for analysis. We were able to do this for a particular example, the infection cycle of the coliphage Q beta .
ISSN:0006-2960
1520-4995
DOI:10.1021/bi00110a001