Amylin, Food Intake, and Obesity

Amylin, also known as islet amyloid polypeptide, identified in 1987, is a naturally occurring hormone, released by the β cells of the pancreas and consists of 37 amino acids. Amylin seems to decrease food intake through both central and peripheral mechanisms and indirectly by slowing gastric emptyin...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2002-10, Vol.10 (10), p.1087-1091
Main Authors: Reda, Tarek K., Geliebter, Allan, Pi‐Sunyer, F. Xavier
Format: Article
Language:English
Subjects:
amylin
Amyloid - chemistry
Amyloid - pharmacology
Amyloid - physiology
Eating - physiology
Female
food intake
gastric emptying
Gastric Emptying - physiology
Humans
Islet Amyloid Polypeptide
Male
Obesity - metabolism
satiety
Satiety Response - physiology
weight loss
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Summary:Amylin, also known as islet amyloid polypeptide, identified in 1987, is a naturally occurring hormone, released by the β cells of the pancreas and consists of 37 amino acids. Amylin seems to decrease food intake through both central and peripheral mechanisms and indirectly by slowing gastric emptying. The mean basal amylin concentration is higher in obese than in lean human subjects. The amylin response to oral glucose is also greater in obese subjects, whether or not they have impaired glucose tolerance. The elevated amylin levels in obesity may lead to down‐regulation of amylin receptors and lessen the impact of postprandial amylin secretion on satiety and gastric emptying. Amylin administration may overcome resistance at target tissues, delay gastric emptying, and have potential for inducing weight loss in obese individuals.
ISSN:1930-7381
1071-7323
1930-739X
1550-8528
DOI:10.1038/oby.2002.147