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Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats
Stimulation of the hippocampal formation can modulate nociceptive mechanisms, whereas painful stimuli can activate this structure. Stress exposure can produce plastic changes in the hippocampus. Nitric oxide (NO) is an important neuroregulatory agent present in the hippocampus. The objective of the...
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Published in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-12, Vol.74 (1), p.149-156 |
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container_title | Pharmacology, biochemistry and behavior |
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description | Stimulation of the hippocampal formation can modulate nociceptive mechanisms, whereas painful stimuli can activate this structure. Stress exposure can produce plastic changes in the hippocampus. Nitric oxide (NO) is an important neuroregulatory agent present in the hippocampus. The objective of the present study was to investigate the effects of intrahippocampal administration of
N
ω-nitro-
l-arginine methyl ester hydrochloride (
l-NAME), an inhibitor of NO synthase (NOS), on nociceptive processes in stressed and nonstressed rats. Male Wistar rats (
n=6–11/group) received unilateral microinjection of
l-NAME (50–300 nmol/0.2 μl) into the dentate gyrus (DG) of the dorsal hippocampus. Immediately after the injection tail-flick reflex latency was measured. Stressed animals were submitted to 2 h of restraint and tested immediately or 1, 2, 5 or 10 days later.
l-NAME failed to modify nociception in nonstressed rats. However, 5 days after, restraint
l-NAME, at all doses tested, produced an antinociceptive effect (ANOVA,
P |
doi_str_mv | 10.1016/S0091-3057(02)00964-4 |
format | article |
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N
ω-nitro-
l-arginine methyl ester hydrochloride (
l-NAME), an inhibitor of NO synthase (NOS), on nociceptive processes in stressed and nonstressed rats. Male Wistar rats (
n=6–11/group) received unilateral microinjection of
l-NAME (50–300 nmol/0.2 μl) into the dentate gyrus (DG) of the dorsal hippocampus. Immediately after the injection tail-flick reflex latency was measured. Stressed animals were submitted to 2 h of restraint and tested immediately or 1, 2, 5 or 10 days later.
l-NAME failed to modify nociception in nonstressed rats. However, 5 days after, restraint
l-NAME, at all doses tested, produced an antinociceptive effect (ANOVA,
P<.05). The dose–response curve had an inverted U shape.
l-NAME antinociceptive effect was antagonized by previous treatment with
l-arginine (150 nmol/0.2 μl,
P<.05). The results suggest that the modulation of nociceptive processes by NO in the dorsal hippocampus is dependent on previous stress exposure and on poststress interval.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(02)00964-4</identifier><identifier>PMID: 12376162</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Analgesia ; Animals ; Antinociception ; Biological and medical sciences ; Dentate Gyrus - drug effects ; Dentate Gyrus - enzymology ; Dose-Response Relationship, Drug ; Enzyme Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Male ; Microinjections ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric oxide ; Nitric Oxide - physiology ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase Type I ; Pain Measurement - drug effects ; Rats ; Rats, Wistar ; Reaction Time - drug effects ; Restraint stress ; Restraint, Physical ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Stereotaxic Techniques ; Stress, Psychological - enzymology ; Stress, Psychological - psychology ; Stress-induced analgesia ; Tail-flick ; Vertebrates: nervous system and sense organs</subject><ispartof>Pharmacology, biochemistry and behavior, 2002-12, Vol.74 (1), p.149-156</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-174770caf6f151a212bf5631ef3710a140e90175a5da358e23bd6092585946123</citedby><cites>FETCH-LOGICAL-c422t-174770caf6f151a212bf5631ef3710a140e90175a5da358e23bd6092585946123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14391654$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12376162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Echeverry, Marcela B</creatorcontrib><creatorcontrib>Guimarães, Francisco S</creatorcontrib><creatorcontrib>Oliveira, Marina A</creatorcontrib><creatorcontrib>do Prado, William A</creatorcontrib><creatorcontrib>Del Bel, Elaine A</creatorcontrib><title>Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Stimulation of the hippocampal formation can modulate nociceptive mechanisms, whereas painful stimuli can activate this structure. Stress exposure can produce plastic changes in the hippocampus. Nitric oxide (NO) is an important neuroregulatory agent present in the hippocampus. The objective of the present study was to investigate the effects of intrahippocampal administration of
N
ω-nitro-
l-arginine methyl ester hydrochloride (
l-NAME), an inhibitor of NO synthase (NOS), on nociceptive processes in stressed and nonstressed rats. Male Wistar rats (
n=6–11/group) received unilateral microinjection of
l-NAME (50–300 nmol/0.2 μl) into the dentate gyrus (DG) of the dorsal hippocampus. Immediately after the injection tail-flick reflex latency was measured. Stressed animals were submitted to 2 h of restraint and tested immediately or 1, 2, 5 or 10 days later.
l-NAME failed to modify nociception in nonstressed rats. However, 5 days after, restraint
l-NAME, at all doses tested, produced an antinociceptive effect (ANOVA,
P<.05). The dose–response curve had an inverted U shape.
l-NAME antinociceptive effect was antagonized by previous treatment with
l-arginine (150 nmol/0.2 μl,
P<.05). The results suggest that the modulation of nociceptive processes by NO in the dorsal hippocampus is dependent on previous stress exposure and on poststress interval.</description><subject>Analgesia</subject><subject>Animals</subject><subject>Antinociception</subject><subject>Biological and medical sciences</subject><subject>Dentate Gyrus - drug effects</subject><subject>Dentate Gyrus - enzymology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Male</subject><subject>Microinjections</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - physiology</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase Type I</subject><subject>Pain Measurement - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reaction Time - drug effects</subject><subject>Restraint stress</subject><subject>Restraint, Physical</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Stereotaxic Techniques</subject><subject>Stress, Psychological - enzymology</subject><subject>Stress, Psychological - psychology</subject><subject>Stress-induced analgesia</subject><subject>Tail-flick</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhi0EomnhJ4B8AZXDwozXH8mpQuVTqsQBOFuOd0yMNt5geyvy73GaiB57skd63hl7HsZeILxFQP3uO8AKux6UuQTxphVadvIRW-DS9J1CYx6zxX_kjJ2X8hsApNDmKTtD0RuNWixY-kCj29PAS81UShfTMPtWulRjmnz0tKvxljiFQL7yKfAUa46eT3_jQLzsU924QjymTVzHGqfUrrxuiA-UqqvEf-3zXA7B7Gp5xp4ENxZ6fjov2M9PH39cf-luvn3-ev3-pvNSiNqhkcaAd0EHVOgEinVQukcKvUFwKIFWgEY5NbheLUn060HDSqilWkndfnfBXh_77vL0Z6ZS7TYWT-PoEk1zsUagAangQRCXbawC1UB1BH2eSskU7C7Hrct7i2APRuydEXtYtwVh74xY2XIvTwPm9ZaG-9RJQQNenQBXvBtDdsnHcs_JfoVaHRpdHTlqe7uNlG3xkVKTFXNTY4cpPvCUfwB8p6M</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Echeverry, Marcela B</creator><creator>Guimarães, Francisco S</creator><creator>Oliveira, Marina A</creator><creator>do Prado, William A</creator><creator>Del Bel, Elaine A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats</title><author>Echeverry, Marcela B ; Guimarães, Francisco S ; Oliveira, Marina A ; do Prado, William A ; Del Bel, Elaine A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-174770caf6f151a212bf5631ef3710a140e90175a5da358e23bd6092585946123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>Antinociception</topic><topic>Biological and medical sciences</topic><topic>Dentate Gyrus - drug effects</topic><topic>Dentate Gyrus - enzymology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Male</topic><topic>Microinjections</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - physiology</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase Type I</topic><topic>Pain Measurement - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reaction Time - drug effects</topic><topic>Restraint stress</topic><topic>Restraint, Physical</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Stereotaxic Techniques</topic><topic>Stress, Psychological - enzymology</topic><topic>Stress, Psychological - psychology</topic><topic>Stress-induced analgesia</topic><topic>Tail-flick</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Echeverry, Marcela B</creatorcontrib><creatorcontrib>Guimarães, Francisco S</creatorcontrib><creatorcontrib>Oliveira, Marina A</creatorcontrib><creatorcontrib>do Prado, William A</creatorcontrib><creatorcontrib>Del Bel, Elaine A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Echeverry, Marcela B</au><au>Guimarães, Francisco S</au><au>Oliveira, Marina A</au><au>do Prado, William A</au><au>Del Bel, Elaine A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>74</volume><issue>1</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Stimulation of the hippocampal formation can modulate nociceptive mechanisms, whereas painful stimuli can activate this structure. Stress exposure can produce plastic changes in the hippocampus. Nitric oxide (NO) is an important neuroregulatory agent present in the hippocampus. The objective of the present study was to investigate the effects of intrahippocampal administration of
N
ω-nitro-
l-arginine methyl ester hydrochloride (
l-NAME), an inhibitor of NO synthase (NOS), on nociceptive processes in stressed and nonstressed rats. Male Wistar rats (
n=6–11/group) received unilateral microinjection of
l-NAME (50–300 nmol/0.2 μl) into the dentate gyrus (DG) of the dorsal hippocampus. Immediately after the injection tail-flick reflex latency was measured. Stressed animals were submitted to 2 h of restraint and tested immediately or 1, 2, 5 or 10 days later.
l-NAME failed to modify nociception in nonstressed rats. However, 5 days after, restraint
l-NAME, at all doses tested, produced an antinociceptive effect (ANOVA,
P<.05). The dose–response curve had an inverted U shape.
l-NAME antinociceptive effect was antagonized by previous treatment with
l-arginine (150 nmol/0.2 μl,
P<.05). The results suggest that the modulation of nociceptive processes by NO in the dorsal hippocampus is dependent on previous stress exposure and on poststress interval.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12376162</pmid><doi>10.1016/S0091-3057(02)00964-4</doi><tpages>8</tpages></addata></record> |
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subjects | Analgesia Animals Antinociception Biological and medical sciences Dentate Gyrus - drug effects Dentate Gyrus - enzymology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus Male Microinjections NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type I Pain Measurement - drug effects Rats Rats, Wistar Reaction Time - drug effects Restraint stress Restraint, Physical Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Stereotaxic Techniques Stress, Psychological - enzymology Stress, Psychological - psychology Stress-induced analgesia Tail-flick Vertebrates: nervous system and sense organs |
title | Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats |
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