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Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

Many proteins lead a dual existence as both membrane-bound and soluble isoforms. One that has recently received a great deal of attention is the amyloid precursor protein (APP), a C-terminally anchored transmembrane protein that is released by a specific proteolytic cleavage near the membrane anchor...

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Published in:	Biochemistry (Easton) 1991-10, Vol.30 (42), p.10065-10074
Main Authors:	Ehlers, Mario R. W, Riordan, James F
Format:	Article
Language:	English
Subjects:	amyloid protein Animals Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Endopeptidases Fundamental and applied biological sciences. Psychology Hydrolysis Membrane Proteins - metabolism Molecular and cellular biology reviews Solubility Stereoisomerism
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container_issue	42
container_start_page	10065
container_title	Biochemistry (Easton)
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creator	Ehlers, Mario R. W Riordan, James F
description	Many proteins lead a dual existence as both membrane-bound and soluble isoforms. One that has recently received a great deal of attention is the amyloid precursor protein (APP), a C-terminally anchored transmembrane protein that is released by a specific proteolytic cleavage near the membrane anchor to generate a soluble form. While the functions of either form remain speculative, it has been postulated that inappropriate or aberrant cleavage of the APP leads to the generation of beta -amyloid deposits that are associated with Alzheimer's disease and Down syndrome. This has prompted considerable interest in the proteases that may be involved in this process since they would be prime targets for the design of therapeutic agents.
doi_str_mv	10.1021/bi00106a001
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source	ACS CRKN Legacy Archives
subjects	amyloid protein Animals Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Endopeptidases Fundamental and applied biological sciences. Psychology Hydrolysis Membrane Proteins - metabolism Molecular and cellular biology reviews Solubility Stereoisomerism
title	Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins
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