The coagulation cascade: initiation, maintenance, and regulation

There are two principal mechanisms to stop the loss of blood in higher organisms following vascular injury. The reactions set the stage for the coagulation cascade and fibrin formation by making available negatively charged phospholipids such as phosphatidylserine on the surface of the activated pla...

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Bibliographic Details
Published in:Biochemistry (Easton) 1991-10, Vol.30 (43), p.10363-10370
Main Authors: Davie, Earl W, Fujikawa, Kazuo, Kisiel, Walter
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Coagulation - physiology
Blood Coagulation Factors - physiology
Blood coagulation. Blood cells
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods, hemostasis, fibrinolysis
Humans
Molecular and cellular biology
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Summary:There are two principal mechanisms to stop the loss of blood in higher organisms following vascular injury. The reactions set the stage for the coagulation cascade and fibrin formation by making available negatively charged phospholipids such as phosphatidylserine on the surface of the activated platelets or damaged cell membranes.
ISSN:0006-2960
1520-4995
DOI:10.1021/bi00107a001