Expression of the p75 neurotrophin receptor by striatal cholinergic neurons following global ischemia in rats is associated with neuronal degeneration

The induction of the p75 neurotrophin receptor (p75NTR) on striatal cholinergic neurons by global hypoxic-ischemia has been reported to promote neuron survival. We have found, however, while the p75NTR-expressing neurons survive the insult for the first 5 days, subsequently they undergo shrinkage, l...

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Bibliographic Details
Published in:Neuroscience letters 2002-10, Vol.332 (1), p.57-60
Main Authors: Greferath, U, Mallard, C, Roufail, E, Rees, S.M, Barrett, G.L, Bartlett, P.F
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Ischemia - metabolism
Brain Ischemia - pathology
Cell death
Cholinergic Fibers - metabolism
Cholinergic interneurons
Corpus Striatum - metabolism
Corpus Striatum - pathology
Global ischemia
Immunohistochemistry
Medical sciences
Nerve Degeneration - metabolism
Nerve Degeneration - pathology
Neurology
Neurotrophin receptor
Rats
Rats, Wistar
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor - biosynthesis
Striatum
Vascular diseases and vascular malformations of the nervous system
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Summary:The induction of the p75 neurotrophin receptor (p75NTR) on striatal cholinergic neurons by global hypoxic-ischemia has been reported to promote neuron survival. We have found, however, while the p75NTR-expressing neurons survive the insult for the first 5 days, subsequently they undergo shrinkage, loss of choline acetyl transferase (ChAT) expression, and more than 96% are eventually lost by 8 days. In contrast ChAT-expressing cells in the surrounding region of the infarction, do not express p75NTR and there is no evidence of neuronal loss. These results suggest the expression of p75NTR on cholinergic interneurons of the rat striatum is associated with delayed neuronal degeneration.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00928-X