Role of Endogenous Nitric Oxide Generation in the Regulation of Vascular Tone and Reactivity in Small Vessels as Investigated in Transgenic Mice Using Synchrotron Radiation Microangiography

Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays a central role in regulation of vascular tone and reactivity. The purpose of this study is to clarify the basal tone and microvascular reactivity in eNOS-overexpressing transgenic (Tg) mice in vivo with a microangiography system usin...

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Bibliographic Details
Published in:Nitric oxide 2001-10, Vol.5 (5), p.494-503
Main Authors: Yamashita, Tomoya, Kawashima, Seinosuke, Ozaki, Masanori, Namiki, Masayuki, Satomi-Kobayashi, Seimi, Seno, Tadashi, Matsuda, Yasuaki, Inoue, Nobutaka, Hirata, Ken-ichi, Akita, Hozuka, Umetani, Keiji, Tanaka, Etsuro, Mori, Hidezo, Yokoyama, Mitsuhiro
Format: Article
Language:English
Subjects:
Angiography - methods
Animals
Cattle
endothelial nitric oxide synthase
Enzyme Inhibitors - pharmacology
Hindlimb - blood supply
Hindlimb - diagnostic imaging
In Vitro Techniques
Lipopolysaccharides - metabolism
Mice
Mice, Transgenic
microangiography
microvascular reactivity
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle Relaxation - drug effects
Muscle Relaxation - physiology
Muscle, Smooth, Vascular - physiology
Neovascularization, Physiologic
NG-Nitroarginine Methyl Ester - pharmacology
nitric oxide
Nitric Oxide - physiology
Nitric Oxide Synthase - physiology
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Nitroprusside - pharmacology
Papaverine - pharmacology
synchrotron radiation
Synchrotrons - instrumentation
transgenic mouse
vascular tone
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays a central role in regulation of vascular tone and reactivity. The purpose of this study is to clarify the basal tone and microvascular reactivity in eNOS-overexpressing transgenic (Tg) mice in vivo with a microangiography system using monochromatic synchrotron radiation (SR). The mouse femoral artery was cannulated, nonionic contrast media was injected, and microangiography was performed in hindlimbs of mice. Serial images of the small blood vessels (diameter
ISSN:1089-8603
1089-8611
DOI:10.1006/niox.2001.0376