Versatile computerized system for tracking and analysis of water maze tests

A crucial step in the estimation of properties of compounds in behavioral experiments is the quantification and description of the different effects observed. The goal of the present work was the automation of the Morris water maze test, one of the most popular behavioral methods for the study of an...

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Bibliographic Details
Published in:Behavior research methods, instruments, & computers instruments, & computers, 2001-08, Vol.33 (3), p.371-380
Main Authors: Mukhina, T V, Bachurin, S O, Lermontova, N N, Zefirov, N S
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Behavior, Animal
Behavioral Sciences - methods
Computing Methodologies
Maze Learning
Observation - methods
Rats
Videotape Recording
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Summary:A crucial step in the estimation of properties of compounds in behavioral experiments is the quantification and description of the different effects observed. The goal of the present work was the automation of the Morris water maze test, one of the most popular behavioral methods for the study of animal memory. An original system was developed that provides fast and accurate tracking of animals, storage of the results in the database and video archive and a means of analyzing the results. This computerized version of the Morris water maze test permits the quantification of such vague characteristics of cognitive function as the "directionality" of search of the hidden platform after a standard training series. The suggested parameters made it possible to discriminate cognitive properties of the novel compounds from other behavioral effects affecting escape latency. The effectiveness of this system was demonstrated in two experiments with neurochemically lesioned and drug-treated rats.
ISSN:0743-3808
1532-5970
DOI:10.3758/BF03195391