HTLV‐1 decreases Th2 type of immune response in patients with strongyloidiasis

• Published in: Parasite immunology 2001-09, Vol.23 (9), p.503-507
• Main Authors: Porto, Aurélia F., Neva, Franklin A., Bittencourt, Helito, Lisboa, Waldir, Thompson, Robert, Alcântara, Luís, Carvalho, Edgar M.
• Format: Article
• Language: English
• Subjects: Adult; Animals; Antibodies, Helminth - blood; Cells, Cultured; Cytokines - biosynthesis; Cytokines - blood; HTLV-I Infections - blood; HTLV-I Infections - complications; HTLV-I Infections - immunology; HTLV‐1; Human T-lymphotropic virus 1; Human T-lymphotropic virus 1 - immunology; Humans; IgE; Immunoglobulin E - blood; Interferon-gamma - blood; Interleukin-10 - blood; Interleukin-13 - blood; Interleukin-5 - blood; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - immunology; S. stercoralis; Strongyloides stercoralis; Strongyloides stercoralis - immunology; strongyloidiasis; Strongyloidiasis - blood; Strongyloidiasis - complications; Strongyloidiasis - immunology; Th2 Cells - immunology
• ISSN: 0141-9838; 1365-3024
• DOI: 10.1046/j.1365-3024.2001.00407.x

Eosinophils, immunoglobilin (Ig)E and cytokines have important roles in defence mechanisms against helminths. In this study, the influence of HTLV‐1 infection, characterized by a Th1 type of immune response, was evaluated on the cytokine pattern and parasitic specific IgE response in patients with strongyloidiasis. Patients were divided into four groups: strongyloidiasis without HTLV‐1 infection, strongyloidiasis with HTLV‐1, HTLV‐1 without strongyloidiasis and controls without either helminth infection or HTLV‐1. The cytokine profile was determined in supernatants of mononuclear cells stimulated with Strongyloides stercoralis crude antigen and the parasite specific IgE was measured by ELISA. Patients coinfected with HTLV‐1 had higher levels of interfron (IFN)‐γ and interleukin (IL)‐10 (P