Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus

• Published in: Arthritis and rheumatism 2002-10, Vol.46 (10), p.2665-2672
• Main Authors: Bosma, G. P. Th, Middelkoop, H. A. M., Rood, M. J., Bollen, E. L. E. M., Huizinga, T. W. J., Van Buchem, M. A.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Atrophy; Biological and medical sciences; Brain - pathology; Disability Evaluation; Female; Humans; Lupus Vasculitis, Central Nervous System - pathology; Lupus Vasculitis, Central Nervous System - physiopathology; Magnetic Resonance Imaging - methods; Medical sciences; Middle Aged; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
• ISSN: 0004-3591; 1529-0131
• DOI: 10.1002/art.10574

Objective To investigate the relationship between quantitative estimates of global brain damage based on magnetization transfer imaging (MTI) and cerebral functioning, as measured by neurologic, psychiatric, and cognitive assessments, as well as disease duration in patients with a history of neuropsychiatric systemic lupus erythematosus (NPSLE). Methods In a clinically heterogeneous group of 24 female patients (age range 19–65 years, mean age 35 years) with a history of NPSLE, the correlation values of several volumetric MTI measures and an estimate of cerebral atrophy, neurologic functioning (Kurtzke's Expanded Disability Status Scale [EDSS]), psychiatric functioning (the Hospital Anxiety and Depression Scale [HADS]), and cognitive functioning (cognitive impairment score [CIS] derived from the revised Wechsler Adult Intelligence Scale), as well as several measures of disease duration were assessed using Pearson's correlation coefficient. Results Quantitative volumetric estimates of global brain damage based on MTI and a measure of global brain atrophy correlated significantly with the EDSS, HADS, and CIS scores. No significant correlation was found between the quantitative estimates of global brain damage and the measures of disease duration. Conclusion The results of this study demonstrate that volumetric MTI parameters and cerebral atrophy reflect functionally relevant brain damage in patients with NPSLE. Furthermore, the absence of a linear relationship between disease duration and results of volumetric MTI measures and atrophy suggests a complicated pattern of accumulating brain damage in patients with NPSLE.