Oestrogenicity and effect on hepatic metabolism of the aqueous extract of the leaf mixture of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis

The aqueous extract of the leaf mixtures of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis given by oral route to immature female rats, at doses of 13, 49 and 94 mg/kg per day for 15 days induced a significant increase in ovarian and uteri weight as well as serum...

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Bibliographic Details
Published in:Fitoterapia 2002-10, Vol.73 (6), p.472-478
Main Authors: Telefo, P.B, Moundipa, P.F, Tchouanguep, F.M
Format: Article
Language:English
Subjects:
Acanthaceae
Administration, Oral
Aloe
Aminopyrine N-demethylase
Aminopyrine N-Demethylase - metabolism
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Estradiol - blood
Estradiol - metabolism
Female
Female rats
Fertility Agents, Female - administration & dosage
Fertility Agents, Female - pharmacology
Fertility Agents, Female - therapeutic use
General pharmacology
Hibiscus
Liver - drug effects
Liver - enzymology
Medical sciences
Oestradiol
Ovary
Ovary - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Rats
Rats, Wistar
Uterus - drug effects
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Summary:The aqueous extract of the leaf mixtures of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis given by oral route to immature female rats, at doses of 13, 49 and 94 mg/kg per day for 15 days induced a significant increase in ovarian and uteri weight as well as serum and ovarian oestradiol. Moreover, a significant decrease in liver of aminopyrine N-demethylase activity was noticed in treated animals.
ISSN:0367-326X
DOI:10.1016/S0367-326X(02)00177-6