Elevated immunoreactive-adrenomedullin levels in the aqueous humor of patients with uveitis and vitreoretinal disorders

To clarify possible involvement of adrenomedullin in the pathophysiology of inflammation of eyes, we measured immunoreactive-adrenomedullin concentrations in the aqueous humor and plasma obtained from 14 control subjects and 56 patients with uveitis or vitreoretinal disorders. Immunoreactive-adrenom...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2002-10, Vol.23 (10), p.1865-1868
Main Authors: Udono, Tetsuo, Takahashi, Kazuhiro, Abe, Toshiaki, Shibahara, Shigeki, Tamai, Makoto
Format: Article
Language:English
Subjects:
Adrenomedullin
Adult
Aged
Aqueous Humor - metabolism
Calcitonin Gene-Related Peptide - blood
Calcitonin Gene-Related Peptide - metabolism
Diabetic Retinopathy - metabolism
Eye
Female
Humans
Male
Middle Aged
Peptides - blood
Peptides - metabolism
Retina
Retinal detachment
Uveitis
Uveitis - metabolism
Vitreoretinopathy, Proliferative - metabolism
Vitreous
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Summary:To clarify possible involvement of adrenomedullin in the pathophysiology of inflammation of eyes, we measured immunoreactive-adrenomedullin concentrations in the aqueous humor and plasma obtained from 14 control subjects and 56 patients with uveitis or vitreoretinal disorders. Immunoreactive-adrenomedullin levels in the aqueous humor were significantly elevated in patients with active uveitis, proliferative vitreoretinopathy and proliferative diabetic retinopathy, as compared with control subjects. The plasma immunoreactive-adrenomedullin levels were not significantly correlated with the aqueous humor levels. These findings suggest that adrenomedullin produced locally in the eyes is involved in the pathophysiology of uveitis and some proliferative vitreoretinal disorders.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(02)00145-6