CD8 T cells are sufficient to mediate allorecognition and allograft rejection

Different T cell subsets may play different roles in allorecognition and allograft rejection. It has been suggested that CD8 T cells can only initiate rejection with help from CD4 T cells. Since CD8 T cells may have different requirements for allorecognition and for costimulation, it is important to...

Full description

Saved in:
Bibliographic Details
Published in:Cellular immunology 2002-03, Vol.216 (1), p.6-14
Main Authors: Halamay, Kate E, Kirkman, Robert L, Sun, Linhong, Yamada, Akira, Fragoso, Ruben C, Shimizu, Koichi, Mitchell, Richard N, McKay, Dianne B
Format: Article
Language:English
Subjects:
2C mouse
Acute allograft rejection
Allorecognition
Animals
CD8 T cells
CD8-Positive T-Lymphocytes - physiology
Graft Rejection - immunology
Heart Transplantation - immunology
Homozygote
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Antigen, T-Cell - genetics
Transgenic mouse
Transplantation
Transplantation, Homologous - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Different T cell subsets may play different roles in allorecognition and allograft rejection. It has been suggested that CD8 T cells can only initiate rejection with help from CD4 T cells. Since CD8 T cells may have different requirements for allorecognition and for costimulation, it is important to clarify the role of CD8 cells in rejection. We examined the role of CD8 cells in allorecognition using a TCR transgenic mouse transplantation model. In our study, CD8 cells were able to recognize alloantigens and reject allografts in the absence of help from CD4 T cells. Furthermore our study provides a model to study the mechanisms of CD8-mediated allograft rejection. It may be important in the future, to consider that CD8 T cells may need to be targeted independently of CD4 T cells in strategies used to prevent rejection and induce tolerance.
ISSN:0008-8749
1090-2163
DOI:10.1016/S0008-8749(02)00530-0