Intracerebroventricular injection of exendin (5–39) increases food intake of layer-type chicks but not broiler chicks

• Published in: Brain research 2001-10, Vol.915 (2), p.234-237
• Main Authors: Tachibana, Tetsuya, Sugahara, Kunio, Ohgushi, Atsushi, Ando, Ryuichi, Sashihara, Kouichi, Yoshimatsu, Takao, Furuse, Mitsuhiro
• Format: Article
• Language: English
• Subjects: Animals; Animals, Newborn - physiology; Biological and medical sciences; Broiler chick; Chickens; Eating - drug effects; Eating - physiology; exendin; Exendin (5–39); Feeding; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glucagon - administration & dosage; Glucagon - antagonists & inhibitors; Glucagon-Like Peptide 1; Injections, Intraventricular; Layer-type chick; Peptide Fragments - administration & dosage; Peptide Fragments - antagonists & inhibitors; Protein Precursors - administration & dosage; Protein Precursors - antagonists & inhibitors; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(01)02943-2

To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5–39) on food intake. Intracerebroventricular co-injection of exendin (5–39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5–39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.