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Family cancer history and susceptibility to oral carcinoma in Puerto Rico

BACKGROUND Use of alcohol and tobacco are the major risk factors for cancers of the oral cavity and pharynx in most of the world. A heritable component to oral carcinoma risk also has been suggested, although only limited data are available on familial aggregation of this disease. METHODS A populati...

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Published in:Cancer 2001-10, Vol.92 (8), p.2102-2108
Main Authors: Morris Brown, Linda, Gridley, Gloria, Diehl, Scott R., Winn, Deborah M., Harty, Lea C., Otero, Eleuterio Bravo, Fraumeni, Joseph F., Hayes, Richard B.
Format: Article
Language:English
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Summary:BACKGROUND Use of alcohol and tobacco are the major risk factors for cancers of the oral cavity and pharynx in most of the world. A heritable component to oral carcinoma risk also has been suggested, although only limited data are available on familial aggregation of this disease. METHODS A population‐based case–control study of 342 subjects with carcinomas of the oral cavity and pharynx (oral carcinoma) and 521 controls was conducted in Puerto Rico. The relation between family history of carcinomas of the oral cavity, the upper aerodigestive tract (UADT), and other selected sites with risk of oral carcinoma was explored using logistic regression modeling techniques. RESULTS Risk of oral carcinoma was elevated for subjects reporting a first‐degree relative with carcinoma of the oral cavity (odds ratio [OR], 2.5; 95% confidence interval [CI], 0.8–8.0) or any UADT carcinoma (OR, 2.6; 95% CI, 1.4–4.8). The increased risk associated with family history of UADT carcinoma tended to be greatest for subjects with known risk factors (i.e., heavy consumption of alcohol and/or tobacco and infrequent intake of raw fruits and vegetables) and with oral carcinoma diagnoses at ages younger than 65 years. CONCLUSIONS These findings are consistent with a heritable component to oral carcinoma, although shared lifestyle risk factors may be partially involved. Cancer 2001;92:2102–8. © 2001 American Cancer Society. Risks of oral carcinoma were elevated for subjects reporting a first‐degree relative with oral carcinoma (odds ratio [OR], 2.5) or any upper aerodigestive tract carcinoma (OR, 2.6) in a population‐based study in Puerto Rico of 342 cases with oral carcinoma and 521 controls. These findings are consistent with a heritable component to oral carcinoma, although shared lifestyle risk factors may be partially involved.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(20011015)92:8<2102::AID-CNCR1551>3.0.CO;2-9