Synthesis and characterisation of a new amphotericin b–methoxypoly(ethylene glycol) conjugate

The reaction of methoxypoly(ethylene glycol)-4-nitrophenyl carbonate with amphotericin B has been used to prepare a new conjugate of amphotericin B (mPEG-AmB). A preliminary screening of in vitro antifungal activity has suggested that mPEG-AmB posseses a similar effect and a similar spectrum of acti...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2001-11, Vol.11 (21), p.2833-2835
Main Authors: Sedlák, Miloš, Buchta, Vladimı́r, Kubicová, Lenka, Šimůnek, Petr, Holčapek, Michal, Kašparová, Pavla
Format: Article
Language:English
Subjects:
Amphotericin B - chemical synthesis
Amphotericin B - chemistry
Amphotericin B - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Spectrophotometry, Ultraviolet
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Summary:The reaction of methoxypoly(ethylene glycol)-4-nitrophenyl carbonate with amphotericin B has been used to prepare a new conjugate of amphotericin B (mPEG-AmB). A preliminary screening of in vitro antifungal activity has suggested that mPEG-AmB posseses a similar effect and a similar spectrum of activity as the conventional amphotericin B formulated with sodium desoxycholate. A preliminary screening of in vitro antifungal activity of conjugate mPEG-AmB posseses a similar effect and a similar spectrum of activity as the conventional amphotericin B formulated with sodium desoxycholate.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00532-7