pRb2/p130 Protein expression is correlated with clinicopathologic findings in patients with oral squamous cell carcinoma

• Published in: Cancer 2001-10, Vol.92 (8), p.2117-2125
• Main Authors: Tanaka, Nobuyuki, Ogi, Kazuhiro, Odajima, Tetsuyo, Dehari, Hironari, Yamada, Shunpei, Sonoda, Tomoko, Kohama, Geniku
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; clinicopathologic findings; Cox proportional hazards regression analysis; Female; Grade 3 mode of carcinoma invasion; Humans; Immunohistochemistry; Male; Medical sciences; Middle Aged; Mouth Neoplasms - metabolism; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Neoplasm Staging; oral squamous cell carcinoma; Otorhinolaryngology. Stomatology; p130 protein; Phosphoproteins - metabolism; pRb2/p130 protein; Prognosis; Proportional Hazards Models; Proteins; Rb2 gene; Retinoblastoma Protein - metabolism; Retinoblastoma-Like Protein p130; Survival Analysis; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(20011015)92:8<2117::AID-CNCR1553>3.0.CO;2-O

BACKGROUND pRb2/p130 is one of the retinoblastoma (Rb) gene family and a suppressor oncogene. Immunohistochemically, the expression of pRb2/p130 was reported to be correlated inversely with the degree of malignancy in lung carcinoma and endometrial carcinoma. In the current study, the correlation between expression of pRb2/p130 and clinicopathologic factors in oral squamous cell carcinoma was investigated. METHODS One hundred twenty‐two specimens from patients with oral squamous cell carcinoma were investigated by staining with a polyclonal antibody against pRb2/p130. The correlation between the expression of pRb2/p130 and various clinicopathologic factors was studied. RESULTS Positive staining for pRb2/p130 was observed in 61 of 122 cases (50.0%). pRb2/p130 expression was found to be correlated significantly with clinical stage (P = 0.050), cervical lymph node metastasis (P = 0.035), and tumor differentiation (P = 0.050). In the entire group a significantly reduced 5‐year cumulative survival rate was observed in patients with pRb2/p130‐negative tumors compared with patients whose tumors positively expressed pRb2/p130 (P = 0.0004). When tested with Cox proportional hazards regression analysis, the most significant independent prognostic factor for the entire group of 122 patients was found to be pRb2/p130 expression. CONCLUSIONS Expression of pRb2/p130 may be a good prognostic indicator in patients with oral squamous cell carcinoma and also may be utilized for the subclassification of tumors with the Grade 3 mode of carcinoma invasion. Cancer 2001;92:2117–25. © 2001 American Cancer Society. Immunohistochemical investigation of pRb2/p130 is useful for understanding the biologic behavior of oral squamous cell carcinoma, which indicates that the prognosis of patients with pRb2/p130 positive tumors is good.