Effects of putative galanin antagonists M35 and C7 on rat exocrine pancreas

Galanin is a neuropeptide having a wide range of biological actions. Recently selective galanin receptor antagonists such as M35 [galanin(1-12)-Pro-bradykinin(2-9)-amide] and C7 [galanin(1-12)-Pro-spantide-amide] have been described. These antagonists have blocked the actions of galanin on flexor re...

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Bibliographic Details
Published in:Journal of physiology, Paris Paris, 2001, Vol.95 (1), p.385-389
Main Authors: Kisfalvi Jr, István, Rácz, Gábor, Bálint, András, Máté, Miklós, Oláh, Attila, Zelles, Tivadar, Vizi, E.Sylvester, Varga, Gábor
Format: Article
Language:English
Subjects:
Amylase secretion
Amylases - antagonists & inhibitors
Amylases - secretion
Animals
Bradykinin - analogs & derivatives
Bradykinin - pharmacology
Chimeric analogues
Dose-Response Relationship, Drug
Drug Combinations
Galanin
Galanin - antagonists & inhibitors
Galanin - pharmacology
Male
Pancreas
Pancreas - drug effects
Pancreas - enzymology
Peptide Fragments - pharmacology
Rats
Rats, Wistar
Receptor
Sincalide - pharmacology
Substance P - analogs & derivatives
Substance P - pharmacology
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Summary:Galanin is a neuropeptide having a wide range of biological actions. Recently selective galanin receptor antagonists such as M35 [galanin(1-12)-Pro-bradykinin(2-9)-amide] and C7 [galanin(1-12)-Pro-spantide-amide] have been described. These antagonists have blocked the actions of galanin on flexor reflex, glucose-induced insulin secretion, and acetyicholine release from hippocampus. Our present aim was to investigate whether M35 and C7 can affect galanin-induced inhibition of pancreatic enzyme secretion in rats. Pancreatic enzyme secretion was studied in urethane-anesthetized rats supplied with jugular vein catheter and pancreatic cannula. Amylase secretion evoked by submaximal CCK-8 stimulation was inhibited dose-dependently by galanin in anesthetized rats. Surprisingly, neither M35 nor C7 was able to inhibit the responses of the exocrine pancreas to galanin. However, both putative galanin receptor antagonists behaved as agonists in our experimental models. Our data suggest that the effects of galanin on pancreatic enzyme secretion are not mediated by M35- or C7-sensitive galanin receptors. Therefore, these galanin receptors are different from those described in the central nervous system.
ISSN:0928-4257
1769-7115
DOI:10.1016/S0928-4257(01)00052-3