Vitamin D3–Upregulated Protein-1 (VDUP-1) Regulates Redox-Dependent Vascular Smooth Muscle Cell Proliferation Through Interaction With Thioredoxin

ABSTRACT—Reactive oxygen species are important cellular signaling molecules, and thioredoxin (TRX) is a key regulator of cellular redox balance. We investigated the interaction of TRX with its endogenous inhibitor, vitamin D3–upregulated protein (VDUP)-1, in human aortic smooth muscle cells (SMCs)....

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Bibliographic Details
Published in:Circulation research 2002-10, Vol.91 (8), p.689-695
Main Authors: Schulze, P Christian, De Keulenaer, Gilles W, Yoshioka, Jun, Kassik, Kimberly A, Lee, Richard T
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Adenoviridae - genetics
Biological and medical sciences
Blood vessels and receptors
Carrier Proteins - genetics
Carrier Proteins - physiology
Cell Division
Cell Nucleus - metabolism
Cells, Cultured
Fundamental and applied biological sciences. Psychology
Genetic Vectors
Humans
Models, Biological
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - metabolism
Oxidation-Reduction
Oxidative Stress
RNA, Messenger - biosynthesis
Space life sciences
Thioredoxins - genetics
Thioredoxins - metabolism
Transfection
Vertebrates: cardiovascular system
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Summary:ABSTRACT—Reactive oxygen species are important cellular signaling molecules, and thioredoxin (TRX) is a key regulator of cellular redox balance. We investigated the interaction of TRX with its endogenous inhibitor, vitamin D3–upregulated protein (VDUP)-1, in human aortic smooth muscle cells (SMCs). Adenoviral gene transfer of TRX enhanced TRX enzyme activity 2.7±0.4-fold (P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.0000037982.55074.F6