Advancing animal models of neoplasia through in vivo bioluminescence imaging

Malignant disease is the final manifestation of complex molecular and cellular events leading to uncontrolled cellular proliferation and eventually tissue destruction and metastases. While the in vitro examination of cultured tumour cells permits the molecular dissection of early pathways in tumorig...

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Bibliographic Details
Published in:European journal of cancer (1990) 2002-11, Vol.38 (16), p.2128-2136
Main Authors: Edinger, M., Cao, Y.-a., Hornig, Y.S., Jenkins, D.E., Verneris, M.R., Bachmann, M.H., Negrin, R.S., Contag, C.H.
Format: Article
Language:English
Subjects:
Animal model
Animals
Bioluminescence
Diagnostic Imaging - methods
Diagnostic Imaging - standards
Forecasting
Imaging
In vivo
Luminescent Measurements
Mice
Models, Animal
Neoplasms - diagnosis
Neoplasms - therapy
Sensitivity and Specificity
Tumour
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Summary:Malignant disease is the final manifestation of complex molecular and cellular events leading to uncontrolled cellular proliferation and eventually tissue destruction and metastases. While the in vitro examination of cultured tumour cells permits the molecular dissection of early pathways in tumorigenesis on cellular and subcellular levels, only interrogation of these processes within the complexity of organ systems of the living animal can reveal the full range of pathophysiological changes that occur in neoplastic disease. Such analyses require technologies that facilitate the study of biological processes in vivo, and several approaches have been developed over the last few years. These strategies, in the nascent field of in vivo molecular and cellular imaging, combine molecular biology with imaging modalities as a means to real-time acquisition of functional information about disease processes in living systems. In this review, we will summarise recent developments in in vivo bioluminescence imaging (BLI) and discuss the potential of this imaging strategy for the future of cancer research.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(02)00410-0